College football action gets under way Friday night with five games, capped off by tonight’s TCU vs Arizona Big 12 clash in Tucson. The No. 22 Wildcats host the Horned Frogs in Friday’s lone ranked contest, and an appetizer to Saturday’s heavy slate of Top 25 clashes. With tight point spreads across the board tonight, here’s a quick look at the schedule and odds for each.
Week 10 Top 25 Schedule
*Rob Gray-Imagn ImagesThe Week 10 college football schedule features ranked matchups across the Big 12, SEC, and Big Ten, starting with Friday night’s ranked showdown in Tucson and continuing through Saturday’s national broadcast slate. The action opens Friday evening on FS1, transitions to major Saturday morning kickoffs, and runs through late-night conference games. See key games on the Week 10 schedule below:
Friday 10:15 PM ET – TCU at #22 Arizona (FS1) Saturday 12:00 PM ET – #9 BYU at #3 Utah (ABC) Saturday 12:00 PM ET – #7 Texas at #18 Missouri (ESPN) Saturday 12:00 PM ET – #8 UCLA at Minnesota (Fox) Saturday 12:00 PM ET – Clemson at Syracuse (ESPN2) Saturday 12:00 PM ET – Florida State at Boston College (ACCN) Saturday 3:30 PM ET – #5 Alabama at #14 LSU (ABC) Saturday 3:30 PM ET – #23 Oregon at #12 Ohio State (CBS) Saturday 3:30 PM ET – Cincinnati at #17 Houston (Fox) Saturday 3:30 PM ET – Penn State at Washington (FS1) Saturday 6:00 PM ET – #25 Boise State at Colorado State (USA Net) Saturday 6:15 PM ET – #6 Kentucky at #13 Tennessee (ESPN) Saturday 7:30 PM ET – #1 Miami at #11 Notre Dame (NBC) Saturday 7:30 PM ET – #2 Georgia at #10 Ole Miss (ABC) Saturday 7:45 PM ET – Oklahoma at #24 Florida (SECN) Saturday 9:30 PM ET – West Virginia at #15 Texas Tech (ESPN)TCU vs Arizona Odds
Oct 10, 2026; Morgantown, West Virginia, USA; Arizona Wildcats quarterback Noah Fifita (1) throws a pass during the first quarter against the West Virginia Mountaineers at Milan Puskar Stadium. Mandatory Credit: Ben Queen-Imagn ImagesExpect a competitive Big 12 clash in Tucson where Arizona enters as a home favorite behind quarterback Noah Fifita and a passing attack that tests every secondary. For Arizona to cover the spread or secure a conference win, Fifita needs to avoid turnovers against a TCU secondary that looks to jump short routes and force third-down stops.
On the other side, TCU relies on quarterback Jaden Craig to drive their passing attack. Their secondary will aim to limit downfield targets while forcing Arizona into long conversion attempts. Expect a close battle that comes down to line execution in the fourth quarter.
Spread: Arizona -6.5 (-118) | TCU +6.5 (-102) Moneyline: Arizona -270 | TCU +220 Total (Over/Under): 46.5 points (Over -112 / Under -108)*Odds via DraftKings Sportsbook & current at writingRest of Friday’s CFB Schedule
Beyond tonight’s featured game in Tucson, Friday’s schedule features four additional matchups. SMU hosts Virginia Tech in ACC action with the Mustangs looking to push the pace against a Hokies team built on the ground attack. Meanwhile, Nebraska travels to Illinois for a Big Ten battle decided by defensive line play and turnover margin.
In American Conference play, East Carolina holds a slim home edge against South Florida in a game expected to feature low scoring. Rounding out the rest of the evening, New Mexico takes on Nevada in Mountain West action, with the Lobos taking a productive rushing attack on the road against a Wolf Pack defensive front aiming to slow down early-down runs.
COLLEGE FOOTBALL FRIDAY ODDS GAME LINES Matchup Spread Total Moneyline Today · 7:00 PM ET VT Virginia Tech +6.5 -110 O 56.5 -110 +185 @ SMU SMU -6.5 -110 U 56.5 -110 -225 Today · 7:30 PM ET USF South Florida +1.5 -118 O 39.5 -108 -102 @ ECU East Carolina -1.5 -102 U 39.5 -112 -118 Today · 8:00 PM ET NEB Nebraska -4 -112 O 50.5 -110 -192 @ ILL Illinois +4 -108 U 50.5 -110 +160 Today · 9:00 PM ET UNM New Mexico -10 -110 O 38.5 -108 -410 @ NEV Nevada +10 -110 U 38.5 -112 +320 Today · 10:15 PM ET TCU TCU +6.5 -102 O 46.5 -112 +220 @ 22 ARIZ Arizona -6.5 -118 U 46.5 -108 -270 Odds via DraftKings Sportsbook | Current at writingAlways Remember To Bet Responsibly
Night games in hostile home venues bring high energy, and game momentum can shift quickly. Keeping your wagering strategy disciplined is essential:
Set a Clear Budget: Establish a strict bankroll limit before kickoff and stick to it regardless of outcomes. Avoid Chasing Losses: Stay patient and avoid forcing live bets if early props fail to hit. Follow Official Reports: Check final injury updates and active roster lists right before game time. Use Betting Controls: Take advantage of deposit caps, time-outs, and self-exclusion tools inside sportsbook apps to keep betting fun and controlled.21+. Gambling problem? Call 1-800-GAMBLER. Responsible Gaming Resources
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