The Athletics led by 1 when rookie Justin Sterner (1-1) took over for Luis Severino to start the seventh. Dezenzo sent his fourth pitch 416 feet to center field for his second homer this season to tie it at 3-all.
Houston's Lance McCullers Jr. allowed five hits and three runs in a season-long six innings in his fifth start after missing more than two seasons with injuries.
Jacob Wilson homered with two RBIs for the Athletics, who fell to 3-17 in their last 20 games.
Christian Walker was hit on the hand with a pitch to start Houston's fourth. He left in the bottom of the sixth because of the hit. Manager Joe Espada said Walker was hit on the top of his hand near his knuckles and X-rays were negative.
Key stat
McCullers struck out 12 to tie a career high he last reached in 2018.
Up next
LHP Jacob Lopez (0-2, 2.57 ERA) will start for the Athletics on Thursday night in the opener of a four-game series at Toronto. The Astros open a four-game series against Tampa Bay on Thursday night with RHP Ryan Gusto (3-2, 4.58) on the mound against RHP Shane Baz (4-3, 4.94).
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