Despite their ubiquity, not every star who's used them has had positive experiences in their efforts to speed up their slimming down, with several celebrities lamenting the nausea they suffered on the drugs, others saying they simply didn't work for them and at least one star admitting they were distraught at constipation they suffered while on Ozempic.
Whether there's a financial incentive to their endorsements (and several of them are paid spokespersons for weight loss drugs, because even while promoting the idea that thin is in, they still want their wallets to be fat), or they're just trying to promote a more honest culture around body image and setting more realistic standards for women, these celebs have all spoken publicly about using Ozempic and its ilk to drop pounds.
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Celebrities on Ozempic and Other Weight Loss Drugs
Anthony Anderson
Anthony Anderson in January 2024Kevin Winter/Getty Images
"I will say this," he told PEOPLE. "It's creating a shortage for those of us who need the medicine that we need and not for weight loss issues, but for our health."
Related: How Much Weight Can You Expect to Lose On Ozempic?
Remi Bader
Remi Bader in February 2026Photo by Dave Benett on Getty Images
"I had a lot of mixed feelings [about using Ozempic]," she said. "A few months later I went off it and got into the bad binging."
She eventually underwent bariatric surgery, she revealed to Self in 2025, and was pictured in February 2026 looking more svelte than ever.
Related: What Happens When You Stop Taking Ozempic
Charles Barkley
Charles Barkley in September 2024Photo by Derek White on Getty Images
"There’s so many different ways to lose weight," he said on his King James CNN show. "There’s no shoe size that fits all. But I gained 105 pounds ... and a friend of mine says, 'Yo, man, I want you to go to this doctor,' because I can’t eat less and work out enough to lose 100 pounds. And [the doctor] says, 'Try this drug.' And I started taking Mounjaro. And I have lost 65 pounds. I started my journey at 355 pounds. I played at 250. I’m down to 285."
He reportedly had to stop using it temporarily due to shortages, leading him to gain 12 pounds back, but said he wanted to go back on to lose another 15 pounds.
Kathy Bates
Kathy Bates in January 2026Photo by Robin L Marshall on Getty Images
"I’ve recently gone on Ozempic and everybody said, ‘Oh, she did it with Ozempic,’ but that’s not true," Bates said on The Drew Barrymore Show. "I started doing that about a year ago for my diabetes and that’s helped me lose the last 15 pounds or so. But even with the Ozempic, I still have to pay attention [to my diet].”
Boy George
Boy George in August 2023Rick Kern/Getty Images
Noting that he also had a tummy tuck, he called semaglutide medications "wonder drugs" and said "anyone who was fat last year and is now skinny" was likely using them.
Bunnie XO
Bunnie XO in February 2026Photo by Taylor Hill on Getty Images
“Both my parents had diabetes. So my insulin numbers are really crazy and my body just cannot tolerate it,” she explained to PEOPLE, adding, “I prided myself on the fact that I only had anxiety. I never had depression. So when you get slammed with suicidal ideation and visions and just, oh, it was horrific.”
Related: Bunnie Xo Details Sex Life Struggles When Jelly Roll Weighed 500 Pounds
Kandi Burruss
Kandi Burruss in February 2026Photo by Bruce Glikas on Getty Images
“Last year, I tried it. I saw so many people who were trying it and losing weight. So I was like, ‘OK, I’m going to try this,’" she said on the Page Six Virtual Reali-tea podcast in June 2025. "And I didn’t lose any weight! My doctor was like, ‘I don’t know what the problem is, I’m not seeing this in other people.’"
"It didn’t curb my appetite," she added. "I know some people are like, ‘Oh, I can’t eat.’ Not me. I was eating appetizers, a regular meal and dessert. It didn’t stop anything for me. It makes you depressed. Realistically, it makes you feel like, ‘What is wrong with me? Why is it not working for me?'"
Dolores Catania
Dolores Catania in November 2023Bravo/Getty Images
Related: The Surprising Benefit of Weight Loss Drugs, According to Obesity Doctors
Savannah Chrisley
Savannah Chrisley in 2024Photo by Chip Somodevilla on Getty Images
“I love food,” she explained her Unlocked podcast. “That’s the hard part. So when I’m on the shot and I can’t eat, I’m like, ‘I really love food.’”
Kelly Clarkson
Kelly Clarkson in June 2024NBC/Getty Images
"My doctor chased me for, like, two years, and I was like, ‘No, I’m afraid of it. I already have thyroid problems,’" she recalled. After she had bloodwork turn out badly, however, she agreed to go on medication to regulate her blood sugar, which in turn sparked some of her weight loss. She said at her heaviest she weighed 203 pounds and didn't even recognize herself, but that she was "happy" regardless of her size.
Related: Ozempic Before and After Pictures
James Corden
James Corden in February 2026Photo by Ian West - PA Images on Getty Images
"What I realized was I was like, 'Oh no, nothing about my eating has anything to do with being hungry,'" he explained on his podcast This Life of Mine (via E! News). "All this does is make you feel not hungry. But I am very rarely eating [just because of hunger]."
Terry Dubrow
Terry Dubrow in May 2024Steve Granitz/Getty Images
After going off the drug, he toldE! Newsthat March, "How am I doing off Ozempic? I'm overweight and chubby. There's more to love, but I'll tell you something: I'm off it, but I plan on going back on it when it's appropriate. Like we have a vacation and after that I'll come back. It's like the new Botox ... I love it. It's so good." (Do note that doctors do not recommend weight loss medications for short-term use or for small-scale weight loss.)
Jennifer Fessler
Jennifer Fessler in November 2023Mindy Small/Getty Images
That December, she revealed she was hospitalized for an impacted bowel, a side effect of her Ozempic use.
Harvey Fierstein
Harvey Fierstein in June 2025Photo by Dimitrios Kambouris on Getty Images
“People don’t understand that being fat is not a choice,” Fierstein explained to Page Six. “It’s something that your body is out of whack and this puts your body in whack.”
"What’s different is what the drug actually does for you, which is: I don’t feel like I’m dieting,” Fierstein said. “I feel like a normal person. I can go and have dinner with friends and not have to eat every piece of bread on the table, and then not go have ice cream when I’ve done with dinner.”
Stephen Fry
Stephen Fry in July 2024Karwai Tang/Getty Images
"The first week or so, I was thinking, ‘This is astonishing. Not only do I not want to eat, I don't want any alcohol of any kind. This is going to be brilliant,’" he recalled in March 2024. "Then I started feeling sick, and I started getting sicker and sicker and sicker. I was literally throwing up four, five times a day and I thought, ‘I can't do this.’ So that's it."
Jim Gaffigan
Jim Gaffigan in November 2025Photo by Jamie McCarthy on Getty Images
"I'm just grateful because it's such a better life," he told PEOPLE, adding, "I almost thought it was kind of odd that people were resistant to talking about it. I don’t think there’s anything wrong with it. There’s people walking around that obviously do not have blonde hair — yet they do. I don’t think that’s weird, either. It’s just whatever gets you through."
He also touched on his weight loss in his November 2024 special The Skinny.
Heather Gay
Heather Gay in November 2023Monica Schipper/Getty Images
"I've been on it for a long time, but hadn't really seen much results," she told PEOPLE in November 2023. "And I haven't had massive results, but enough for people to notice, which is great."
Golnesa "GG" Gharachedaghi
View this post on Instagram"I had to get a lot of steroid injections last year, which caused me to really pack on some weight, and I don't know if it's because I'm 41 years old or I've had a baby," she said in a February 2023 Instagram video. "Whatever it is, I’ve been having a very, very, very hard time getting rid of that weight."
She added, "I encourage it to anybody who's having a hard time losing weight and wants the 'easy route.' Summer's around the corner."
Related: The Best Exercise for People on Ozempic, According to Obesity Doctors
Whoopi Goldberg
Whoopi Goldberg on "The Kelly Clarkson Show" in 2024NBC/Getty Images
Related: What It's Like to Take Ozempic, Week by Week
Jon Gosselin
Jon Gosselin in April 2024Paul Archuleta/Getty Images
"You know what's annoying? The regret of not starting it 10 years ago," he said. "I feel amazing! Like, why didn't I do this sooner? Maybe it wasn't the right time."
Related: Ozempic vs. Metformin: Similarities, Differences, and How to Know What's Best for You
Macy Gray
Macy Gray in March 2025Photo by Scott Dudelson on Getty Images
"Oh, boy my stomach hurts," Macy groaned. "I took Ozempic. I can't go to the bathroom, and I was up all night."
Chelsea Handler
Chelsea Handler in January 2024Kevin Mazur/Getty Images
"I didn't even know I was on it. She said, 'If you ever want to drop five lbs., this is good,'" Handler recalled on the Call Her Daddy podcast. She said she injected herself with it after a vacation and soon learned a friend of hers also used the medication and complained she was nauseous from it.
She added, "I've injected about four or five of my friends with Ozempic because I realized I didn't wanna use it cause it's silly. It's for heavy people. Everyone is on Ozempic. It's gonna backfire, something bad is gonna happen."
Related: Top Foods to Limit If You're On Ozempic, According to Obesity Doctors
Sunny Hostin
Sunny Hostin in July 2024Taylor Hill/Getty Images
"During COVID, I gained 40 pounds. All I did was eat," she said onThe View(viaPEOPLE). "I love to cook, and I found out, I love to eat. And I was horrified about the fact that I would have to come out on air. So I also took Mounjaro."
"I found that my cholesterol went up to 200 when I gained the extra weight. I use Mounjaro and my cholesterol is 140 now," she said. "I feel better, I think I look better, and that's what this is about for people."
Related: The #1 Ozempic Mistake People Make, According to Obesity Doctors
Margaret Josephs
Margaret Josephs in February 2026Photo by Bruce Glikas on Getty Images
"It shuts off that food noise, my blood work is great. [Before Ozempic] I couldn’t do anything," she said. "It doesn't matter if I was eating right or exercising. So I don't know why there's any shame in it if it's helpful to people."
Related: How to Get Prescribed Ozempic for Weight Loss
Billie Jean King
Billie Jean King in January 2026Photo by Robin Marchant on Getty Images
“If [weight loss medication] does quiet the voices—if that’s a part of it—now I’m [into] it because that would be really great, because that gets exhausting and tiring," she told Julia Louis-Dreyfus on her Wiser Than Me podcast. "And I don’t want to fight over these things."
Lauren Manzo
View this post on Instagram"I think it's being abused because I see people, Housewives, that are posting and you literally see their ribs, and it's sad because you were already skinny," she explained. "That is a bad thing for somebody like me who has suffered from high blood pressure and anxiety from being super heavy and depression. People that are already 130 pounds and just want to lose 10 more, and they want to stay on it—that, I don't respect."
Gracie McGraw
Gracie McGraw in May 2023Manny Carabel/Getty Images
Related: The No. 1 Weight Loss Secret, According to Obesity Doctors
Tracy Morgan
Tracy Morgan in November 2023Mike Coppola/Getty Images
"I went and got a prescription, and I got Ozempic," he said on TODAY in August 2023. "I ain't letting it go. It cuts my appetite in half. Now I only eat half a bag of Doritos."
Elon Musk
Elon Musk in January 2024Anadolu/Getty Images
Interestingly, Musk's own Grok chatbot says that President Donald Trump was referring to the Tesla CEO when he made a crack about a "seriously overweight" friend who told him he was taking the "fat shot," to which the former Apprentice host replied, "It's not working." Too bad he couldn't use that chainsaw to cut his calories.
Rosie O'Donnell
View this post on Instagram"Ok so went shopping to (buy) a comfy lounge wear outfit for my 22 hour flight to australia- was undecided as i cant see myself in this new smaller body," she captioned a photo in August 2025. "Cam n robin took this photo of me in the dressing room — i am shocked im a 12 — #mounjaro is a life saver ?❤️??"
Kelly Osbourne
Kelly Osbourne in February 2026Photo by Dave Benett on Getty Images
In May 2025, however, she admitted to at least trying some type of unspecified medication at one point, saying, “I tried probably everything that there is out there, whether it be surgery, medication, diet and exercise. I got my mind where I needed it to be, and everything started to fall into place.”
Since then, Osbourne has lost even more weight, which she attributed to the grief of losing her father, Ozzy Osbourne, in July 2025.
Sharon Osbourne
Sharon Osbourne in February 2026Photo by Samir Hussein on Getty Images
"You can't stay on it forever. I lost 42 pounds now and it's just—enough," she said on Piers Morgan Uncensored in September 2023. "I didn’t want to go this thin. It just happened."
She also noted that she got so thin that her husband Ozzy Osbournebegan calling her "Nancy Reagan."
Related: How Common Is Nausea on Ozempic?
Claudia Oshry
Claudia Oshry in May 2024Sarah Kerver/Getty Images
Internet personalityClaudia Oshrylost 70 pounds on Ozempic, but said her hair was shedding as a side effect of the drug—and that since going off of it, she was hungry all the time.
Amy Schumer
Amy Schumer in October 2025Photo by XNY/Star Max on Getty Images
"I tried it," she said on Watch What Happens Live in June 2023. "I was one of those people that felt so sick and couldn't play with my son. I was so skinny and he's throwing a ball at me and [I couldn't]."
That said, Schumer has had no issues posting and boasting about her 50-poundMounjaro weight loss (and even deleting all her past Instagram photos) after she invested in a company that sells it.
June "Mama June" Shannon
June "Mama June" Shannon in May 2025Photo by Michael Simon on Getty Images
After previously undergoing a gastric sleeve surgery documented in her reality show Mama June: From Not to Hot, Mama June Shannongained some of her weight back. She turned to weight loss injections to help her on her weight loss journey and encouraged fans to talk to their physicians to find out what medications or programs can work best for them. She also wants to help patients find lower-cost alternatives for and generic versions of expensive prescriptions.
Emily Simpson
Emily Simpson in November 2023Mindy Small/Getty Images
Related: Ozempic Butt: Causes, Side Effects, How to Get Rid of It
Tori Spelling
Tori Spelling in April 2024Jesse Grant/Getty Images
Tori Spellingsaid she struggled to lose weight after the birth of her son Beau in 2017, and that she turned to a weight loss injection for help—but to no avail and that she's no longer on it. "I did Mounjaro and everyone admits it now. It’s a different time so I don’t feel shamed saying that," she said. "I did whatever anyone told me to do that was safe and it just wasn’t working. The weight wouldn’t come off."
Caroline Stanbury
View this post on Instagram"I used Ozempic, which I think is one of the best tools if you’re able to use it. What did Kate Moss say? ‘Nothing tastes as good as skinny feels,’" Stanbury said. "There’s something to be said for that."
Related: Does Ozempic Make You Tired? Doctors Discuss Fatigue
Patti Stanger
Patti Stanger in January 2024Frazer Harrison/Getty Images
She still uses other weight loss drugs, however, today.
"I waited, and all my hairdresser friends went on Mounjaro," she said on the Behind the Velvet Rope podcast. "I'm not diabetic, but I do take a sugar pill twice a day to keep my sugar down. So my doctor recommended it, and she said, 'I'll give you the vial of Tirzepatide,' which is the ingredient [in Mounjaro]."
Eric Stonestreet
Eric Stonestreet in July 2025Photo by Cindy Ord on Getty Images
He told PEOPLE, “It’s a game changer. It has just been incredible. It’s changed my lifestyle, changed my approach to eating, changed my approach to exercise.”
Chrissy Teigen
Chrissy Teigen in February 2026Photo by Michael Buckner on Getty Images
“My body was completely stuck,” she said on her Self-Conscious podcast. “I really let myself indulge when I was pregnant. So, when I had lost that baby at 20 weeks, I had probably gained an extra 40 pounds that I wasn’t comfortable with.”
Meghan Trainor
Meghan Trainor in August 2025Photo by Peacock on Getty Images
The "Been Like This" singer wrote on Instagram in March 2025, "No, I don't look like I did 10 years ago. I've been on a journey to be the healthiest, strongest version of myself for my kids and for me. I’ve worked with a dietician [sic], made huge lifestyle changes, started exercising with a trainer and yes, I used science and support (shoutout to Mounjaro!) to help me after my 2nd pregnancy. And I’m so glad I did because I feel great."
Trainor also got a breast augmentation as part of her makeover.
Sheryl Underwood
Sheryl Underwood in February 2023Unique Nicole/Getty Images
"I'm about three different sizes because I still got a booty," she said, joking that she's a "baby Kardashian."
Related: What Happens if You Eat Too Much Sugar on Ozempic, According to Obesity Doctors
Serena Williams
Serena Williams in November 2025Photo by Michael Buckner on Getty Images
She explained to TODAY, “A misconception is that [weight loss medication] is a shortcut. As an athlete and as someone that has done everything, I just couldn’t get my weight to where I needed to be at a healthy place—and believe me, I don’t take shortcuts.”
Vanessa Williams
Vanessa Williams in February 2026Photo by Bruce Glikas on Getty Images
"When I turned 60, I was like: ‘I want to be here for a long time, and I want to look my best. So what am I going to do?’" the singer, actress and former model told Hello! Magazine. "My fifties were hard. I started perimenopause in my late forties but suddenly, at 51, it’s crazy how your body changes. You feel out of control because you’re working out the same way, eating the same, and your body is not reacting the way it used to."
Related: Ozempic Shortage? What to Do, According to Doctors
Rebel Wilson
Rebel Wilson in July 2024Jeff Spicer/Getty Images
Related: Ozempic Breasts: Doctors Explain What It Is and How to Treat It
Oprah Winfrey
Oprah Winfrey in January 2024Amy Sussman/Getty Images
"The fact that there's a medically approved prescription for managing weight and staying healthier, in my lifetime, feels like relief, like redemption, like a gift, and not something to hide behind and once again be ridiculed for," she told PEOPLE. "I'm absolutely done with the shaming from other people and particularly myself."
Related: A Large New Study on Weight Loss Drugs Like Wegovy Has Good News if You’re Looking To Reduce Your Heart Attack Risk
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