The duo - who have played the beloved Karl and Susan Kennedy since 1994 - are preparing to say farewell to the cult soap this week, after it failed to be recommissioned by producers Amazon MGM Studios in February.
Uniquely, and rather sadly, this is a position they've both been in before. It was just over three years ago that the show wrapped up the Ramsay Street drama with a blaze of highly publicised returns, including Kylie Minogue and Margot Robbie, a wedding party on the infamous cul de sac and a sense of hope for the future.
The more finite storyline, while allowing the door to remain open for a potential revival, signifies a change in gear from last time. If Neighbours was to return - and given this is the third time that the series has been pulled since it began - it would be very different.
"There was tears, there was sadness, Stefan [Dennis] spoke beautifully on the last day," Fletcher explains to RadioTimes.com.
Woodburne adds: "Ironically, there was a sense of, 'Well, who knows?', especially the way the story ended. There was an element of hope. And we have lived the experience of you really do never know."
"What logistically would be the easiest and the least expensive to shoot? Where do Karl and Susan best fit in? I mean, really, you could justify any of the three options," she continues.
"For Susan, obviously, the hope is that they would save Ramsay Street, but logistically, I doubt that's possible."
Amid the speculation, they also want fans to manage their expectations and not be sat waiting for a reprieve. In fact, they've both moved onto new ventures. For Fletcher, he's just completed a nationwide UK tour with his music, while Woodburne is set to lead a new 5 drama, Imposter, which hits screens next week.
"It's just the reality. So who knows what the future is? Paying for television [production] these days is so hard and so fraught that you just don't know what sort of show would even be possible."
There's still a lot to look forward to in the last few days. A range of old faces return in the finale, allowing Neighbours to do what it does best - dipping into the rich history of the characters and playing on the nostalgia a little.
"I think having Shane pitted against Paul at the end, there was a perfect blend, if you like."
Concluding, they both wanted to share their gratitude with those who have supported their careers, and the show, over the years.
And for Fletcher? "It's a total ditto for me. I do have a very, very close personal connection with a lot of people who, over the years, have come to all the gigs. So actually, I know people now on a different level, and they tell me about what's going on in their lives and what Neighbours means to them.
The final episode of Neighbours streams on Amazon Prime Video from 7.30am on Thursday, 11th December.
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Neighbours is available to stream on Prime Video.
Check out more of our Soaps coverage or visit our TV Guide and Streaming Guideto find out what's on. For more TV recommendations and reviews, listen to The Radio Times Podcast.
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