Seahawks loss to 49ers 28-16 in week 14

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Seahawks will be without their starting quarterback for Sunday's game against the NFC West-leading 49ers.

Geno Smith, who injured his groin in practice on Thursday and was listed as questionable on the injury report, tested the injury in a pregame workout, and is inactive for Sunday's game at Levi's Stadium.

Russell Wilson to Denver.

"He's been waiting for this opportunity, looking forward to it and preparing for it," Seahawks coach Pete Carroll said of Lock on Friday. "If this comes to pass, then he is as ready as he can get."

Sean Mannion, who signed to the practice squad on Friday, will serve as the backup to Lock.

The San Francisco 49ers returned to Levi's® Stadium on Sunday after spending the last two weeks on the road. In Week 14, the 49ers hosted the Seattle Seahawks for their second meeting in a span of two weeks. San Francisco's first meeting with Seattle came on Thanksgiving night and resulted in a 31-13 takedown of their longtime NFC West rival. This second bout with the Seahawks looked a little different with Seattle backup quarterback Drew Lock under center and the game remaining a close affair through three quarters.

Sean Mannion to their practice squad Friday and elevated him for Sunday's game.

Seattle's other inactives: outside linebacker Frank Clark Sr., wide receiver Dee Eskridge (ribs), offensive tackles McClendon Curtis and Raiqwon O'Neal, and linebacker Patrick O'Connell. The Seahawks announced Saturday that Clark wasn't making the trip to the Bay Area and that he would be inactive for noninjury reasons.

The Seahawks (6-6) were 14.5-point underdogs to the 49ers (9-3) as of Sunday afternoon, according to ESPN BET. San Francisco beat Seattle 31-13 at Lumen Field on Thanksgiving night and has won four straight games over the Seahawks by a combined score of 120-56. The Seahawks have not lost four straight games since Carroll became their head coach in 2010.

Lock started fast with a 31-yard TD pass on the opening drive to DK Metcalf, with Metcalf appearing to celebrate by sending a message in sign language.

Lock added a 25-yarder to Colby Parkinson late in the third quarter to cut the deficit to 21-16, but couldn't get Seattle over the hump.

Lock finished 22 for 31 for 269 yards with two TDs and two interceptions.

“I think it was a blast being out there again,” Lock said. “I’m trying to balance the feeling of just finally playing again, and how good that feels and also not getting it done.”

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