Match prediction 49ers vs. Rams prediction

San Francisco 49ers have won eight of the last nine matchups against the Los Angeles Rams and look to continue that trend on Sunday. Los Angeles' only win in the series was in the 2022 NFC Championship Game, a 20-17 victory that propelled them to a Super Bowl and eventual championship two weeks later. Both teams opened the 2023 season victorious on the road as the 49ers crushed the Steelers, 30-7, and the Rams defeated the Seahawks, 30-13. Last season, San Francisco won this matchup 24-9 at home and 31-14 in LA.

Los Angeles is scheduled for 4:05 p.m. ET. San Francisco is a 7.5-point favorite and the over/under for total points scored is 45 in the latest 49ers vs. Rams odds. Before making any Rams vs. 49ers picks, 

With the 49ers so heavily favored on the moneyline at -350, they’re simultaneously the best bet and a low-profit pick. They are our pick because, as the sportsbooks suggest, San Francisco will throttle LA and hand them their first loss. But, with the odds favoring the 49ers so heavily, you’d need to wager $350 to win $100.

Admittedly, the Rams looked great in their opener against the Seahawks. They won by more than two touchdowns and easily covered as +4.5 point road underdogs. Beating the spread by 21.5 points is a big deal, but expectations should be tempered for a follow-up win.

San Francisco is a different beast than Seattle, as evidenced by its 8-1 record against Los Angeles dating back to 2019 

Colin Kaepernick went to throw for over 400 yards (with at 69% completion percentage) and three touchdowns while the Packers, a major Super Bowl contender, went at the 49ers with absolutely everything they had. While the score was much closer than the 49ers’ 2023 Week 1, it was just as convincing as pundits began to crown them the class of the NFC. Unfortunately, they went to what was then Century Link Field, home of the Seattle Seahawks and got blown out in Week 2. Hopefully the 49ers can keep this strong of a win going this time around. And no, the 2014 Dallas Cowboys opener was not as a convincing win. That game was quickly going the wrong way in the 4th quarter and you could tell something was amiss. Neither was the 2016 Week 1 blowout of the Rams.

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Sarah H

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