New method for asymmetric N,N-acetal synthesis promises advances in drug development ...Middle East

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New method for asymmetric N,N-acetal synthesis promises advances in drug development
Chiral N,N-acetals are an important component of several bioactive drugs and medicines. Owing to this, chemical reactions that lead to high-purity yield of the desired 'enantiomeric' form are highly sought after. In a new study, scientists from Japan demonstrate high selectivity formation of N,N-acetals from reactions between 2-aminobenzamide and various diketones in presence of bis(imidazoline)-phosphoric acid catalyst and look into the possible mechanism, opening doors to facile synthesis of novel pharmaceutical drugs.

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