Richie Wellens' side, who finished one spot above the relegation zone last season despite reaching the play-off final in 2025, have started the campaign well and they sit five points off the top of the table after five games.
Watch Leyton Orient v Wycombe Wanderers on Sky Sports
Leyton Orient and Wycombe Wanderers will be hoping to find form this season to make a push for the play-off spots, however, the latter are still searching for their first win of the campaign.
Wycombe Wanderers, who have been in League One since 2021 after their relegation from the Championship, finished 11th last season and they'll be hoping a new manager will come in and get a tune out of the squad in the coming months.
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Leyton Orient v Wycombe Wanderers kick-off time
Leyton Orient v Wycombe Wanderers will kick off at 12:30pm.
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How to live stream Leyton Orient v Wycombe Wanderers online
Sky Sports customers can live stream the game via the Sky Go app on a variety of devices including most smartphones and tablets as part of their subscription.
NOW can be streamed through a computer or apps found on most smart TVs, phones and consoles. NOW is also available via TNT Sports.
Is Leyton Orient v Wycombe Wanderers on radio?
Unfortunately, this match will not be aired on national radio. Check your local BBC radio station for more information.
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Leyton Orient v Wycombe Wanderers odds
In working partnership with the Radio Times, bet365 has provided the following betting odds for this event:
bet365 odds: Leyton Orient (8/5) Draw (12/5) Wycombe Wanderers (8/5)*
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