New episodes of the mystery drama are currently filming on the French Riviera, with showrunner Mike White spinning us another yarn following an all-new bunch of holidaymakers.
An HBO spokesperson told Deadline that "it had become apparent that the character which Mike White created for Helena Bonham Carter did not align once on set".
The role is now to be reworked to fit White's past collaborator Dern, whom he has previously worked with on HBO comedy-drama Enlightened, which ran for two seasons and earned her a Golden Globe.
However, that won't be the character she's playing in season 4. Rather, the lead character will be a version of Carter's vacant role, but modified to better suit Dern's sensibilities.
She joins a long list of established and rising stars in The White Lotus season 4 cast, including Vincent Cassel (Westworld), Steve Coogan (Legends), Alexander Ludwig (Vikings), Chris Messina (Based on a True Story) and Kumail Nanjiani (Taskmaster).
The daughter of Hollywood veterans Bruce Dern and the late Diane Ladd, Laura Dern has forged a celebrated career including Blue Velvet, Jurassic Park, Star Wars: The Last Jedi and Marriage Story.
On the small screen, she co-starred in both seasons of Big Little Lies and recently spoke hopefully about the prospect of a third, as did creator David E Kelley when he spoke to Radio Times earlier this month.
Check out more of our Drama coverage or visit our TV Guide and Streaming Guide to find out what's on. For more TV recommendations and reviews, listen to The Radio Times Podcast.
Add The White Lotus to your watchlist on the Radio Times: What to Watch app – download now for daily TV recommendations, features and more.
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