WCM-Q research probes mechanisms of premature aging of fat cells in obesity ...Qatar

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WCM-Q research probes mechanisms of premature aging of fat cells in obesity
Researchers at Weill Cornell Medicine-Qatar (WCM-Q) have gained new insight into the molecular mechanisms by which obesity leads to premature aging of fat cells, and then to chronic inflammation, insulin resistance and – eventually - type-2 diabetes. The researchers, led by WCM-Q’s Dr. Nayef Mazloum, developed a new in vitro laboratory test and used gene analysis and editing technologies to discover key molecules that regulate cellular senescence and aging in adipose (fat) cells and examined the function of two protein encoding genes - named STAT1 and STAT3 - in the regulation of inflammation that can lead to insulin resistance and type 2 diabetes. Cellular senescence is a process of deteri

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