Christina Applegate stole the hearts of Americans in the '90s as Kelly Bundy on Fox's hit sitcomMarried... with Children. After an impressive 11-season run as Al and Peg Bundy's daughter, the actress went on to secure numerous roles, including Amy Green — the sister of Jennifer Aniston's character — on the sitcom Friends, and later starred in the iconic 2016 film, Bad Moms.
In 2019, Applegate was back on screens in Netflix's instant hit, Dead To Me, alongside Linda Cardellini. The hilarious duo carried the show through a successful 3-season run, during which Applegate publicly announced that she was suffering from multiple sclerosis (MS) in 2021. Since then, Christina Applegate has used her platform to raise awareness for the debilitating disease that affects nearly 3 million people worldwide.
Friend and Sopranos actress Jamie Lynn Sigler has suffered with MS for 25 years, and in 2025, the two launched their podcast, MeSsy, where they often share intimate details about their disease.
During their most recent episode, Applegate described the relentless exhaustion the illness has inflicted on her body.
View this post on InstagramIn a clip shared by Applegate on Instagram, she can be heard saying, “I’m not tired. I really hate that — when someone says, ‘Oh, you’re tired today.’ No,” she went on to add. “ ‘Oh, you’re fatigued today.’ No. ‘Do you feel like you’re on horse tranquilizers?’ Yes.”
Sigler gave a resounding "yes" in response to Applegate's description.
The horse tranquilizer metaphor resonated with many listeners who share the actresses' diagnosis or have one causing a similar effect:
"As someone with about 20 serious chronic illnesses that all cause serious fatigue, I feel this so much. Thank you for speaking up about things like this. ????," one grateful fan penned.
Another described their experience as, "You feel like you’re carrying weights through water or quicksand."
Several followers showered Applegate with gratitude for openly sharing something that they've had trouble explaining, "??? Thank you for putting into words a feeling I could never quite describe ?," one wrote. "What an amazingly accurate description of how ms feels," said another.
The encouragement continued, "@christinaapplegate you’re doing a beautiful and needed thing by being transparent about your life with MS ?."
Hachette Book Group
Applegate's efforts to raise MS awareness and share her story go beyond her podcast. The Emmy-winning actress has published a "raw and darkly funny" memoir set for an official release date of March 3, 2026. You With the Sad Eyes is available now for pre-ordering through her Instagram handle and the Hachette Book Group's website.
Related: Christina Applegate Debuts the Powerful Cover of Her Memoir 'You With the Sad Eyes': "Chills"
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