Napoli vs Pisa prediction, odds & betting tips 22/09/2025 ...Middle East

Napoli will look to maintain their perfect record in Serie A when they host Pisa at Stadio Diego Armando Maradona on Monday, 22 September 2025.

View our free Napoli vs Pisa predictions below.

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Napoli led at half-time in five of their last seven matches across all competitions.Fewer than three goals were scored in each of Pisa’s last five games.Pisa have scored only once in four competitive matches this season.

Correct score prediction: Napoli 2-0 Pisa

Pisa have lost back-to-back games without scoring and have no wins at the end of regulation time in their last seven matches across all competitions.

On the other hand, Napoli have three wins in as many Serie A games this season, averaging exactly two goals per match while conceding only once.

Taking everything into account, we are confident that Napoli will win-to-nil.

Pre-game odds and win probability: Napoli are overwhelming favourites

*Odds from Ladbrokes, subject to change

Napoli's six-game winning streak across all competitions ended with a 2-0 defeat against Manchester City in the UEFA Champions League last week.

With a perfect three wins from three, the Partenopei, who are currently third, will overtake Juventus for the top spot in Serie A if they win this game.

On the other hand, newly promoted Pisa have earned only one point from three matches and are 18th in the Italian top flight ahead of their encounter with the defending champions.

Bearing that in mind, Napoli are the expected winners at 3/10 (1.30). Teams with these odds generally have a 76.9% probability of winning.

Don’t forget to check out more of our best betting tips and predictions after you’ve dissected our Napoli vs Pisa predictions.

Moreover, Napoli drew first blood in six of their last seven matches, leading at the half-time break in five of them. On that note, HT Napoli to win has an appealing look at 3/4 (1.75). That one has a 57.1% chance of landing.

Most recent H2Hs: First encounter in 18 years

This will be Napoli's first clash with Pisa since August 2007, and their first meeting in Serie A since February 1991.

Interestingly, Napoli have a 9-5-3 win-draw-loss record in 17 previous skirmishes between these outfits.

Goalkeeper Alex Meret is expected to be between the sticks on Monday night, although Vanja Milinkovic-Savic has been excellent in Meret’s absence. However, Amir Rrahmani, Romelu Lukaku and Nikita Contini are ruled out with injuries.

Playing at home, the Partenopei will look to keep their momentum going as they aim to become the first team to defend the league title since Juventus did so in the 2019-20 season.

Predicted lineup: Milinkovic-Savic (GK), Di Lorenzo, Beukema, Buongiorno, Spinazzola, Lobotka, Politano, McTominay, Anguissa, De Bruyne & Hojlund.

Last five matches

Man City 2-0 NapoliFiorentina 1-3 NapoliNapoli 1-0 CagliariSassuolo 0-2 NapoliNapoli 2-1 Olympiacos

Pisa preview: Eyeing their first win

Pisa have no other injury issues for this weekend’s trip to Naples besides former Juventus man Juan Cuadrado, who is certainly unavailable due to a thigh injury.

Predicted lineup: Semper (GK), Canestrelli, Cariaccolo, Lusuardi, Toure, Akinsanmiro, Aebischer, Angori, Moreo, Tramoni & Meister.

Last five matches

Player to watch: Kevin De Bruyne

Kevin De Bruyne has had an impressive season so far, with six goal contributions in as many competitive appearances for club and country. The former Manchester City forward will look to return to scoring ways after failing to score against his former team in the Champions League last week.

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