Entering Sunday’s matchup with the New York Mets (80-74), the Washington Nationals (62-92) are on a five-game losing streak. The contest starts at 1:40 p.m. ET on WPIX and MASN2 with the Mets listed as -265 favorites, while the are +213 underdogs who may be heading for a sixth straight defeat.
New York’s Clay Holmes gets the start, and he’ll go against Washington’s Jake Irvin.
Mets vs. Nationals Odds
Mets odds to win: -265 Nationals odds to win: +213 Spread: Mets -1.5 Total: 8.5 runsMets vs. Nationals Promo Codes
Game Time and Information
Date: Sunday, September 21, 2025 Time: 1:40 p.m. ET TV: WPIX and MASN2Who Will Win Mets vs. Nationals?
Mets and Nationals Betting Trends
The Mets have been the moneyline favorite 109 total times this season. They’ve gone 62-47 in those games.
New York has gone 11-2 when it has played as moneyline favorites with odds of -265 or shorter (84.6% winning percentage).
The Nationals have been underdogs in 135 games this season and won 56 (41.5%) of those contests.
Washington has a record of 3-5 when it’s set as an underdog of +213 or more by sportsbooks this season.
The Mets have played in 154 games with set over/under, and have combined with opponents to go over the total 73 times (73-73-8).
So far this season, the Nationals and their opponents have hit the over in 77 of their 153 games with a total.
Mets Stats & Insights
The Mets are the 10th-highest scoring team in baseball, averaging 4.8 runs per game (734 total).
New York is fourth in MLB action with 214 home runs. They average 1.4 per game.
The Mets are 11th in MLB with a .250 batting average.
New York strikes out 8.2 times per game to rank 12th in MLB.
The 8.7 strikeouts per nine innings compiled by the Mets pitching staff ranks 10th in the majors.
New York has the 16th-ranked team ERA among all MLB pitching staffs (4.02).
Nationals Stats & Insights
The Nationals have scored 653 runs (4.2 per game) this season, which ranks 23rd in MLB.
Washington has hit just 144 homers this season, which ranks 27th in the majors.
The Nationals rank 21st in MLB with a .243 team batting average.
Washington ranks 13th in strikeouts per game (8.2) among MLB offenses.
The Nationals average just 8.7 strikeouts per nine innings as a pitching staff, which ranks 28th in the big leagues.
Washington has the 29th-ranked ERA (5.37) in the majors this season.
Mets Key Players to Watch
Holmes makes the start for the Mets, his 31st of the season. He is 11-8 with a 3.77 ERA and 124 strikeouts in 155 2/3 innings pitched.
Juan Soto leads New York with 42 home runs this season. He’s batting .265 with 103 RBI.
Francisco Lindor is batting .268 with an OBP of .344 and a slugging percentage of .456 this season.
Pete Alonso leads New York in batting average (.272) and runs batted in (122) this season while also slugging 37 homers.
Brandon Nimmo has 145 hits and an OBP of .326 to go with a slugging percentage of .441 this season.
Nationals Key Players to Watch
The Nationals will hand the ball to Irvin (8-13) for his 32nd start of the season.
C.J. Abrams has a team-high batting average of .264.
James Wood’s 27 home runs and 89 runs batted in both lead his team.
Luis Garcia is batting .255 with 28 doubles, a triple, 13 home runs and 26 walks.
Josh Bell is batting .232 with 14 doubles, a triple, 20 home runs and 55 walks.
Mets and Nationals Injuries
Mets: Tyrone Taylor: 10 Day IL (Hamstring), Reed Garrett: 15 Day IL (Elbow), Drew Smith: 60 Day IL (Elbow), Max Kranick: 60 Day IL (Elbow), Griffin Canning: 60 Day IL (Achilles), Frankie Montás: 60 Day IL (Elbow), Christian Scott: 60 Day IL (Elbow), Dedniel Nunez: 60 Day IL (Elbow), A.J. Minter: 60 Day IL (Lat), Danny Young: 60 Day IL (Elbow), Tylor Megill: 60 Day IL (Elbow), Nick Madrigal: 60 Day IL (Shoulder), Jesse Winker: 60 Day IL (Back)
Nationals: Cole Henry: 15 Day IL (Back), Drew Millas: 60 Day IL (Finger), Josiah Gray: 60 Day IL (Elbow), Trevor Williams: 60 Day IL (Elbow), DJ Herz: 60 Day IL (Elbow), Derek Law: 60 Day IL (Forearm), Keibert Ruiz: 7 Day IL (Concussion)
Mets vs. Nationals Prediction
Score Prediction: Mets 5, Nationals 4 Total Prediction: Over 8.5 runsHow to Bet on Mets vs. Nationals
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