The Cleveland Guardians (82-71) will vie for their ninth straight victory when they visit the Minnesota Twins (66-87) on Saturday at 7:10 p.m. ET on MNNT and CLEG. The Guardians are listed as -112 favorites by sportsbooks, while the Twins are -107 underdogs.
Logan Allen will get the ball for Cleveland while Minnesota will counter with Bailey Ober.
Guardians vs. Twins Odds
Guardians odds to win: -112 Twins odds to win: -107 Spread: Guardians -1.5 Total: 8 runsGuardians vs. Twins Promo Codes
Game Time and Information
Date: Saturday, September 20, 2025 Time: 7:10 p.m. ET TV: MNNT and CLEGWho Will Win Guardians vs. Twins?
Guardians and Twins Betting Trends
The Guardians have won 63.1% of the games this season when they were the moneyline favorite (41-24).
Cleveland has gone 41-21 when playing as moneyline favorites with odds of -112 or shorter (66.1% winning percentage).
This season, the Twins have been the underdog 63 times and won 24, or 38.1%, of those games.
This season, Minnesota has won 23 of its 61 games, or 37.7%, when it’s the underdog by at least -107 on the moneyline.
The Guardians have combined with opponents to go over the total 63 times this season for a 63-80-8 record against the over/under.
The Twins and their opponents have gone over the total this season in 72 of their 152 opportunities.
Guardians Stats & Insights
The Guardians score the third-fewest runs in baseball (600 total, 3.9 per game).
Cleveland is 22nd in MLB with 157 total home runs.
The Guardians have the worst batting average in the league (.226).
Cleveland strikes out 8.3 times per game to rank 14th in baseball.
The pitching staff for the Guardians has a collective 8.5 K/9, which ranks 15th in MLB.
Cleveland has the fourth-ranked team ERA among all MLB pitching staffs (3.74).
Twins Stats & Insights
The Twins have scored the 20th-most runs in the league this season with 655 (4.3 per game).
Minnesota has hit 182 homers this season, which ranks 11th in the majors.
The Twins rank 22nd in MLB with a .240 team batting average.
Minnesota ranks 15th in strikeouts per game (8.4) among MLB offenses.
The Twins average the 12th-most strikeouts per nine innings (8.6) in the majors this season.
Minnesota has the 26th-ranked ERA (4.67) in the majors this season.
Guardians Key Players to Watch
Allen (7-11) takes the mound for the Guardians in his 28th start of the season. He’s put together a 4.36 ERA in 144 1/3 innings pitched, with 111 strikeouts.
Jose Ramirez leads Cleveland in batting average (.282), home runs (29) and runs batted in (80) this season.
Steven Kwan has 161 hits and an OBP of .333 to go with a slugging percentage of .375 this season.
Kyle Manzardo has collected 104 base hits, an OBP of .321 and a slugging percentage of .465 this season.
Angel Martinez has 98 hits and an OBP of .272 to go with a slugging percentage of .371 this season.
Twins Key Players to Watch
The Twins’ Ober (5-8) will make his 26th start of the season.
Byron Buxton leads the Twins with 31 home runs and 76 runs batted in, while racking up a team-best batting average of .268.
Trevor Larnach has 22 doubles, a triple, 17 home runs and 53 walks while hitting .253.
Brooks Lee is batting .240 with 15 doubles, a triple, 15 home runs and 30 walks.
Royce Lewis is batting .240 with 16 doubles, 12 home runs and 25 walks.
Guardians and Twins Injuries
Guardians: Nolan Jones: 10 Day IL (Oblique), Lane Thomas: 10 Day IL (Foot), Nic Enright: 15 Day IL (Elbow), Ben Lively: 60 Day IL (Forearm), John Means: 60 Day IL (Elbow), Andrew Walters: 60 Day IL (Lat), Will Brennan: 60 Day IL (Forearm), Sam Hentges: 60 Day IL (Shoulder)
Twins: Matt Wallner: 10 Day IL (Oblique), Christian Vázquez: 10 Day IL (Shoulder), Anthony Misiewicz: 15 Day IL (Shoulder), David Festa: 15 Day IL (Shoulder), Justin Topa: 15 Day IL (Oblique), Alan Roden: 60 Day IL (Thumb), Ryan Jeffers: 7 Day IL (Head), Pablo Lopez: day-to-day (Forearm)
Guardians vs. Twins Prediction
Score Prediction: Twins 6, Guardians 5 Total Prediction: Over 8 runsHow to Bet on Guardians vs. Twins
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