Best bets are available with the NFL going to São Paulo, Brazil as the Kansas City Chiefs (0-0) take on the Los Angeles Chargers (0-0) on September 5, 2025, starting at 8 p.m. ET, airing on YouTube.
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Best Over/Under Bet
O/U Pick: Under (45.5)
Chiefs games went over 45.5 points scored, their current matchup’s total, eight times (out of 17) last year. Last season, six of the Chargers’ 17 games had a combined total higher than 45.5 points scored. The two teams averaged a combined 0.7 more points per game (46.2) a season ago than this matchup’s over/under of 45.5 points. The Chiefs and the Chargers saw their opponents average a combined 8.6 less points per game last season than the over/under of 45.5 set in this matchup. The Chiefs’ average point total in outings last year was 43.9, 1.6 points less than the total in this game. The average total in Chargers games in 2024 was 3.2 less points than the point total of 45.5 for this outing.Best Against the Spread Bet
Pick ATS: Chargers (+3)
Against the spread, Kansas City went 7-9-1 last year. The Chiefs’ ATS record as 3-point favorites or greater was 5-7-1 last year. Los Angeles posted a 12-4-1 record against the spread last year. The Chargers had one win ATS (1-1-1) as underdogs of 3 points or greater last season.Best Moneyline Bet
Moneyline: Chiefs (-166), Chargers (+140)
Prediction: Chiefs 21 – Chargers 20 The Chiefs won all 14 of the games they were listed as the moneyline favorite last season. Kansas City won all 12 games it played as a moneyline favorite with odds of -166 or shorter. Last season, the Chargers were listed as the underdog in four games and failed to win any of those contests. Last season, Los Angeles was at least a +140 underdog on the moneyline two times, losing each of those contests. The implied probability for this matchup (based on the moneyline) says the Chiefs have a 62.4% chance to win.Best Chiefs Prop Bet
Travis Kelce Receptions (Pick: 5.5/Under)
Games (2024) Receptions Rec. Per Game Rec. YPG Rec. TDs 16 97 6.1 51.4 3Best Chargers Prop Bet
Will Dissly Receptions (Pick: 2.5/Under)
Games (2024) Receptions Rec. Per Game Rec. YPG Rec. TDs 15 50 3.3 32.1 2How to Watch Chiefs vs. Chargers
When: Friday, September 5, 2025 at 8 p.m. ET Where: Corinthians Arena in São Paulo, Brazil TV info: YouTube Live Stream: Watch this game on Fubo!Sign up for Fubo to watch the NFL, live sports and entertainment without cable!
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