March Madness 2025: Duke holds as title favorite entering Sweet 16 ...Middle East

The second round of the NCAA Tournament was markedly Cinderella-less. Arkansas is the only double-digit seed remaining in the field after upsetting 2-seed St. John’s. But a John Calipari-led team making the Sweet 16 is exactly what Razorbacks leadership hoped to see when opening up the checkbook to bring the legendary coach to Fayetteville in the offseason.

Vegas is slow to back Calipari’s late-season turnaround. At ESPN Bet, Arkansas is tied with Michigan for the longest odds of any remaining team to win the title this season.

Each of the top 4 seeds in the field remains standing, and as such, they’re the favorites to win the title entering the Sweet 16. They are also the favorites to win their respective regions.

Below, you can find the latest March Madness odds, including odds to win each region and advance to the Final Four. You can see how the odds have changed from the second round here.

National Championship odds

odds via ESPN Bet

NJ, PA, VA, MD, WV, MA, KS, KY, LA, TN, NC, CO, AZ, IA, IL, IN, MI, OH Must be 21+. Gambling problem? Call 1-800-GAMBLER.

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