INDIANAPOLIS – Here is how the 49ers (11-4) graded in Monday night’s 48-27 win over the host Colts (8-7):PASS OFFENSE: ABrock Purdy threw...

It wasn’t so long ago there were those among the fan base and the media openly wondering if giving Brock Purdy a five-year contract worth a...

The 44-year-old grandfather looked like he was throwing the football without a thumb. He had been retired for five years, presumably spendin...

The 49ers’ turbocharged offense led them to a 48-27 win over the Indianapolis Colts on Monday night, giving them a fifth consecutive victory...

By MICHAEL MAROT AP Sports WriterINDIANAPOLIS — Brock Purdy and the San Francisco 49ers kept winning and did their neighbors to the south a...

In the middle of a quarterback shootout, the 49ers saw another one of their key offensive pass options go down.

It was truly a costly mistake.

Linebacker Eric Kendricks will make his 49ers debut Monday night against the Indianapolis Colts as will Jordan James, a fifth-round draft pi...

Philip Rivers and the Indianapolis Colts face Christian McCaffrey and the San Francisco 49ers on Monday Night Football.

Week 16 concludes this evening, with the Colts taking on the 49ers on Monday Night Football.How to Watch Monday Night Football: Colts vs...

The Sleeper promo code NEWSWEEKXL will earn new users a $100 bonus to play on Colts vs. 49ers and NFL games this week.

Monday Night Football brings an interconference matchup that puts the San Francisco 49ers on the road against the Indianapolis Colts. This g...

Week 16 wraps up with a matchup between a playoff team and one trying to keep playoff hopes alive.

"That's the last guy they want to see," an NFL insider said.

Claire Kittle, who is married to 49ers tight end, George Kittle, said it "really hit home" when San Francisco briefly released veteran fullb...