The 49ers’ turbocharged offense led them to a 48-27 win over the Indianapolis Colts on Monday night, giving them a fifth consecutive victory...

By MICHAEL MAROT AP Sports WriterINDIANAPOLIS — Brock Purdy and the San Francisco 49ers kept winning and did their neighbors to the south a...

In the middle of a quarterback shootout, the 49ers saw another one of their key offensive pass options go down.

It was truly a costly mistake.

Linebacker Eric Kendricks will make his 49ers debut Monday night against the Indianapolis Colts as will Jordan James, a fifth-round draft pi...

Philip Rivers and the Indianapolis Colts face Christian McCaffrey and the San Francisco 49ers on Monday Night Football.

Week 16 concludes this evening, with the Colts taking on the 49ers on Monday Night Football.How to Watch Monday Night Football: Colts vs...

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Monday Night Football brings an interconference matchup that puts the San Francisco 49ers on the road against the Indianapolis Colts. This g...

Week 16 wraps up with a matchup between a playoff team and one trying to keep playoff hopes alive.

"That's the last guy they want to see," an NFL insider said.

Claire Kittle, who is married to 49ers tight end, George Kittle, said it "really hit home" when San Francisco briefly released veteran fullb...

The wildest storyline of the NFL season continues tonight as 44-year-old quarterback Philip Rivers will start at quarterback for the second...

New users can score a Kalshi promo code to make trades on prediction markets like Monday Night Football’s matchup between the 49ers and Colt...

It’s time for Monday Night Football!The Colts and 49ers close out Week 16 tonight with playoff implications at stake. Here’s a look at s...