Three-in-one approach boosts the silencing power of CRISPR ...Middle East

The CRISPR-Cas9-based gene editing system has dramatically advanced the field of bioengineering. However, while fusing transcription activator or repressor to dCas9 protein allows targeted alteration of gene expression, the effect is short-term. Now, in a new study, scientists from the USA have developed a dCas9-based epigenetic editing tool that performs robust and long-term silencing of target genes.

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