Skin carries sensors to detect heat and cold that influence each organism's decision to stay in or move out of an environment. The new study, published Oct. 28 in the Journal of Physiology, found that these sensors activate at higher temperatures in female mice, which appears to shift their preferred temperature roughly 7 degrees Fahrenheit (4 degrees Celsius) higher than that of male mice. Testosterone seems to influence this difference in activation.
Proteins in the skin's nerve endings activate in response to warmth or cold. "You can look at them like little electrical generators in the nerve endings," said Dr. Michael Caterina, a neuroscientist at Johns Hopkins University who was not involved in the research.
Beyond humans, it is known that many female animals, including mice and birds, prefer slightly warmer temperatures than their male counterparts do. So the researchers set up an experiment to investigate these differences.
Both male and female mice spent more time at the 91.4 F plate when the second plate was cooler. However, when put next to a plate measuring 100.4 F (38 C), female mice spent significantly more time on the warmer plate than male mice did. The average preferred surface temperature was approximately 89.6 F (32 C) for male mice and 96.8 F (36 C) for female mice.
The role of testosterone
The scientists explored what would happen if they genetically deleted the warmth-detector protein. In male mice, this reduced their avoidance of the warmer plate, suggesting this protein normally sends a signal that discourages them from staying on warmer surfaces. The mice's preferred temperature also rose to about 95 F (35 C), closer to that of females.
The study suggests that testosterone somehow tweaks the function of heat-sensing nerves in the skin. (Image credit: Alllex via Getty Images)The team then tried eliminating or blocking the coolness-detecting protein, finding that males and females didn't avoid the cool plates as strongly as they did before. Female mice also spent less time on the warmer plates, but males' preference for the warmer plates didn't change.
The researchers suspected that sex hormones might help to explain this difference.
Interestingly, giving male mice female hormones, including forms of estrogen and progesterone, did not affect their temperature preferences. And blocking the hormones in female mice also had no effect. These hormones are known to influence other aspects of temperature regulation in the body, though, such as heat dissipation through the skin; but in this case, they didn't seem to affect animals' perception of temperature.
The exact mechanism for how testosterone impacts the sensor proteins is not clear. Because the effect happened over weeks, researchers suggested that it did not directly affect the temperature-sensing proteins. It might instead act indirectly by influencing the activity of genes, but further studies would be needed to confirm this idea.
Related storiesAlthough the researchers did not conduct any tests in humans, McNaughton noted that the same sensor proteins are present in people and that studies with humans suggest that they behave in a similar way.
"What kinds of signals create our daily experiences around temperature is by itself very important," he told Live Science. "It's a big part of understanding ourselves as living beings."
This article is for informational purposes only and is not meant to offer medical advice.
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