City lost 1-0 at home against Brighton in the Premier League on Saturday which means Maresca's men have lost two of their last three outings in all competitions.
Watch RB Leipzig v Man City live on TNT Sports via HBO Max on Amazon Prime Video and Sky Sports
A win for City, who won the Champions League in 2023, would likely see them jump into the top eight play-off spots ahead of their next European showdown against Napoli later this month.
The German side were hammered 4-1 by Real Madrid the last time they played in Europe and although RB Leipzig have won their last three in all competitions, it'll be a tough task to get a result against City.
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RB Leipzig v Man City kick-off time
What TV channel is RB Leipzig v Man City on?
The game will be shown live on TNT Sports 2.
You can also access TNT Sports via HBO Max and stream directly to your smart TV.
Regular subscribers can also stream matches on a variety of devices including laptops, smartphones and tablets via the HBO Max app.
Watch RB Leipzig v Man City live on TNT Sports via HBO Max on Amazon Prime Video and Sky Sports
Is RB Leipzig v Man City on radio?
You can listen to the match on talkSPORT.
talkSPORT is available on DAB radio, predominantly MW 1089 kHz though you may need to check its official website for some localised frequencies for talkSPORT, and like the BBC, you can tune in via most TV packages. You can also listen to talkSPORT online via the website or app.
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RB Leipzig v Man City odds
In working partnership with the Radio Times, bet365 has provided the following betting odds for this event:
bet365 odds: RB Leipzig (17/4) Draw (15/4) Man City (8/15)*
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