The California Highway Patrol's Yuba-Sutter division said officers responded to the crash around 5:27 p.m. on northbound Highway 99, south of Howsley Road.
The driver and front passenger of the Toyota both died at the scene, while the CHP said a rear passenger in the Toyota was transported by air ambulance to UC Davis Medical Center for treatment of major injuries.
The CHP said it is not yet known whether alcohol or drugs played a role in the crash. The cause of the crash remains under investigation.
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