The character, portrayed by Diane Parish for the last two decades, has been experiencing unexplained tiredness in recent episodes, and has been prompted by Sam Mitchell (Kim Medcalf) seek medical attention.
The soap has been working with Blood Cancer UK to ensure the plot is delivered accurately and sensitively.
EastEnders' executive producer, Ben Wadey, said: “It was vital to us that Denise’s storyline is portrayed with sensitivity and care, and we’re grateful to Blood Cancer UK for their advice in helping us tell this story accurately.
Helen Rowntree, CEO of Blood Cancer UK, added: “It’s been a privilege advising the EastEnders team to ensure Denise’s storyline reflects the real experiences of people living with blood cancer and those who care for them.
"Blood cancers, which include leukaemia, lymphoma and myeloma, do not discriminate yet experiences and outcomes can vary significantly, including by ethnicity.
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As viewers will recall, Denise was absent during the flash-forward episode that aired on New Year's Day, that saw the action skyrocket one year into the future. It was implied that she'd have some sort of argument with partner Jack Branning (Scott Maslen) and ran out of the house in anger.
He was sat twiddling his marriage band in his fingers, and was prompted by niece Lauren Beale (Jacqueline Jossa) to focus on a baby, Ethan, who was lying in a Moses basket on the other side of the room.
Later in the episode, Denise was one of the four Walford women lined up as a potential wife for Jack's brother Max (Jake Wood). After he was arrested - putting their wedding in jeopardy - Jack said he'd call the bride to keep her in the loop about what was unfolding.
Could Denise's diagnosis be what brings Libby home?
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Visit our dedicated EastEnders page for all the latest news, interviews and spoilers.
Check out more of our Soaps coverage or visit our TV Guide and Streaming Guide to find out what's on. For more TV recommendations and reviews, listen to The Radio Times Podcast.
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