The Dodgers and Diamondbacks wrap up their opening series at Dodger Stadium on Friday, March 27, with first pitch set for 10:10 p.m. ET. Los Angeles rolled to an 8-2 victory in Game 1, and now attention turns to what Shohei Ohtani can do at the plate in Game 2.
The matchup features Dodgers right-hander Emmet Sheehan (6-3, 2.82 ERA) going against Arizona’s Ryne Nelson (7-3, 3.39 ERA). For bettors, the real question isn’t just who wins the game. It’s whether Ohtani goes deep.
The Current Ohtani Home Run Odds
Sportsbooks have Ohtani listed at +209 to hit 1 or more home runs on Friday night. That’s solid plus-money value on one of the most dangerous hitters in the game, and it’s the kind of prop that draws action every single night he plays.
On the hits side, his props break down like this:
2+ hits: +167 Over 1.5 hits: +167 Under 1.5 hits: -224For total bases:
3+ total bases: +126 Over 1.5 total bases: -137 Under 1.5 total bases: +103For RBIs:
1+ RBI: +112 RBI O/U 0.5 Over: +111These numbers paint a clear picture. Oddsmakers expect Ohtani to make contact and get on base, but they’re pricing in more uncertainty around the home run. That gap between his hits odds and his homer odds is where the interesting value lives.
Oct 27, 2025; Los Angeles, California, USA; Los Angeles Dodgers two-way player Shohei Ohtani (17) hits a solo home run against the Toronto Blue Jays in the seventh inning during game three of the 2025 MLB World Series at Dodger Stadium. Mandatory Credit: Jayne Kamin-Oncea-Imagn ImagesOhtani’s Home Run History Against Arizona
Ohtani has made Chase Field his personal showcase over the years, and he’s shown he can do the same damage when the Diamondbacks come to Dodger Stadium. One of his most notable moments against Arizona came when he launched a two-run blast into Chase Field’s right-field pool, tying the Dodgers’ single-season home run record at the time.
He also faced Arizona late in 2025, pitching six scoreless innings while striking out eight batters. The point is, Ohtani doesn’t look at the Diamondbacks as a tough matchup. He’s produced against them both at the plate and on the mound.
Ohtani batted .282 with 55 home runs and 102 RBIs in 2025, winning his fourth MVP award in the process. He enters 2026 as the most dangerous hitter in baseball. Games like Friday night against Arizona are exactly the kind the books love to price conservatively because the public is going to hammer the over.
What Makes This Prop Interesting on Friday
Nelson held his own against the Dodgers last season. In three games against Los Angeles, including two starts, he posted a 2.77 ERA over 13 innings with 12 strikeouts and just one walk. That’s a solid line, but it came against a different version of this Dodgers offense.
Ohtani bats leadoff, which means he gets more plate appearances than almost anyone else in the lineup. More plate appearances equal more chances to hit the ball out of the park. The four-time unanimous MVP will reprise his role as Dodgers leadoff hitter to open 2026.
There are a few things to think through before placing any Ohtani props tonight:
How deep does Nelson go? If the bullpen enters early, Ohtani gets fresh looks at arms with less experience in high-leverage spots. Dodger Stadium plays fair to hitters. It’s not a pitcher’s park by any stretch. Ohtani went hitless in the opener but showed patience at the plate, walking once and scoring a run. He’s not cold; he’s just getting started. Aug 5, 2025; Los Angeles, California, USA; Los Angeles Dodgers designated hitter Shohei Ohtani (17) is greeted by teammates after scoring during the seventh inning against the St. Louis Cardinals at Dodger Stadium. Mandatory Credit: William Liang-Imagn ImagesHow to Approach the Ohtani Props
The home run prop at +209 is the flashy number, and for good reason. That’s more than two-to-one on the best power hitter in the game. At the same time, the 2+ hits at +167 and the 1+ RBI at +112 offer a slightly safer path to a winning ticket if you believe Ohtani is going to get going in this series.
Some bettors prefer to combine a few of these into a same-game parlay. The odds on each individual market drop when paired together, but the payout grows. Pairing a hit with an RBI, for example, makes sense if you expect Ohtani to come through with runners on base.
If you’re betting a straight homer prop, +209 is a price worth considering given his track record and the fact that Nelson hasn’t faced this version of the Dodgers lineup before. That said, there’s no such thing as a lock in this game. Ohtani can be dominant in multiple ways, and the sportsbooks know that.
FAQ
Is the Ohtani home run prop worth betting at +209?
At +209, you’re being paid more than two to one on a player who hit 55 home runs last season. It’s not a guarantee, but it’s a number worth targeting on a night-by-night basis. Ohtani hit 280 home runs during his MLB career, including 163 solo shots and 87 with a runner on base. The power is very real.
What is the game time for Diamondbacks vs. Dodgers on March 27?
First pitch is scheduled for 10:10 p.m. ET at Dodger Stadium.
Who is pitching for Arizona against Ohtani?
Right-hander Ryne Nelson gets the start for Arizona in Game 2. He finished last season with a 7-3 record and a 3.39 ERA heading into 2026.
Did Ohtani homer in Game 1 of this series?
No. Ohtani went without a home run in the opener, though he reached base and scored a run as the Dodgers won 8-2. The performance wasn’t a red flag by any means.
Oct 25, 2025; Toronto, Ontario, CAN; Los Angeles Dodgers two-way player Shohei Ohtani (17) breaks his bat on a single in the eighth inning against the Toronto Blue Jays during game two of the 2025 MLB World Series at Rogers Centre. Mandatory Credit: John E. Sokolowski-Imagn ImagesResponsible Gambling and Bankroll Management
Sports betting is meant to be entertaining, and keeping it that way starts with how you manage your money. Never bet more than you can afford to lose on any single game or prop. A standard rule of thumb is to limit each individual bet to no more than one to two percent of your total bankroll. This protects you from a bad run wiping you out entirely.
Prop bets like Ohtani home runs can be fun to follow, but they’re also higher-variance wagers. Losing streaks happen even on well-researched bets. Set a budget before the game starts and stick to it regardless of how the action unfolds.
If gambling ever stops being fun or starts to feel like something you need rather than something you choose, that’s the time to step back. Resources are available to help, and reaching out is always the right call. 21+. Gambling problem? Call 1-800-GAMBLER. Responsible Gaming Resources
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