The Cleveland Guardians (83-71) and Bo Naylor (2 HR in his last game) are favored (-126) on the moneyline for their matchup with the Minnesota Twins (66-88) on Sunday at 2:10 p.m. ET on MNNT and CLEG.
Cleveland’s Joey Cantillo and Minnesota’s Simeon Woods Richardson have been named the starters for this contest.
Guardians vs. Twins Odds
Guardians odds to win: -126 Twins odds to win: +106 Spread: Guardians -1.5 Total: 8.5 runsGuardians vs. Twins Promo Codes
Game Time and Information
Date: Sunday, September 21, 2025 Time: 2:10 p.m. ET TV: MNNT and CLEGWho Will Win Guardians vs. Twins?
Guardians and Twins Betting Trends
The Guardians are 41-24 in games they were listed as the moneyline favorite (winning 63.1% of those games).
In games it has played as moneyline favorites with odds of -126 or shorter, Cleveland has a 29-10 record (winning 74.4% of its games).
This season, the Twins have been the underdog 63 times and won 24, or 38.1%, of those games.
Minnesota is 13-24 this season when entering a game as the underdog by +106 or more on the moneyline.
In the 152 games in which bookmakers have set an over/under for the Guardians, they have combined with opponents to go over the total 63 times (63-81-8).
The Twins’ games have gone over the total in 72 of their 153 chances.
Guardians Stats & Insights
The Guardians are the third-lowest scoring team in MLB play averaging 3.9 runs per game (606 total).
Cleveland ranks 21st in MLB action with 162 home runs. They average 1.1 per game.
The Guardians’ .226 batting average ranks last in the majors.
Cleveland’s 8.3 strikeouts per game rank 14th in the majors.
The pitching staff for the Guardians has a collective 8.5 K/9, which ranks 15th in the majors.
Cleveland has a 3.72 team ERA that ranks fourth across all MLB pitching staffs.
Twins Stats & Insights
The Twins have scored the 21st-most runs in the league this season with 655 (4.3 per game).
Minnesota’s 182 home runs rank 11th in Major League Baseball.
The Twins rank 23rd in MLB with a .239 team batting average.
Minnesota ranks 16th in MLB in strikeouts per game with an average of 8.4 Ks per contest.
The Twins have an 8.6 K/9 this season as a pitching staff, which ranks 12th in the big leagues.
Minnesota has pitched to a 4.68 ERA this season, which ranks 26th in baseball.
Guardians Key Players to Watch
Cantillo (5-3 with a 3.27 ERA and 95 strikeouts in 85 1/3 innings pitched) gets the start for the Guardians, his 12th of the season.
Jose Ramirez leads Cleveland in home runs with 30, runs batted in with 81 and his batting average of .282 is also best on his team.
Steven Kwan has 163 hits and an OBP of .335 to go with a slugging percentage of .376 this season.
Kyle Manzardo has collected 104 base hits, an OBP of .319 and a slugging percentage of .460 this season.
Angel Martinez is batting .228 with an OBP of .272 and a slugging percentage of .368 this season.
Twins Key Players to Watch
The Twins will send Woods Richardson (7-4) to the mound for his 21st start this season.
Byron Buxton leads the Twins in home runs (31), runs batted in (76) and has racked up a team-high batting average of .265.
Trevor Larnach has 22 doubles, a triple, 17 home runs and 53 walks while hitting .251.
Brooks Lee has 15 doubles, a triple, 15 home runs and 30 walks while batting .240.
Royce Lewis is hitting .238 with 16 doubles, 12 home runs and 25 walks.
Guardians and Twins Injuries
Guardians: Nolan Jones: 10 Day IL (Oblique), Lane Thomas: 10 Day IL (Foot), Nic Enright: 15 Day IL (Elbow), Ben Lively: 60 Day IL (Forearm), John Means: 60 Day IL (Elbow), Andrew Walters: 60 Day IL (Lat), Will Brennan: 60 Day IL (Forearm), Sam Hentges: 60 Day IL (Shoulder)
Twins: Matt Wallner: 10 Day IL (Oblique), Christian Vázquez: 10 Day IL (Shoulder), Anthony Misiewicz: 15 Day IL (Shoulder), David Festa: 15 Day IL (Shoulder), Justin Topa: 15 Day IL (Oblique), Pablo Lopez: 15 Day IL (Forearm), Alan Roden: 60 Day IL (Thumb), Ryan Jeffers: 7 Day IL (Head)
Guardians vs. Twins Prediction
Score Prediction: Guardians 5, Twins 4 Total Prediction: Over 8.5 runsHow to Bet on Guardians vs. Twins
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