Fantasy Football Defense Rankings Week 16: Best Starts at D/ST ...Middle East

Fantasy Football Expert Justin Edwards looks at the current Fantasy Football Defense rankings and projections for Week 16.

“Looking for Week 16 Streamers at defense? Our Fantasy Football D/ST Rankings will help point you in the right direction.”

2025 Fantasy Football Defense Rankings

*As always, the projections and rankings are courtesy of 4for4’s Fantasy Football Defense rankings! 

Fantasy Football D/ST Rankings, Who Should I Add Off Waiver Wires:

The Kansas City Chiefs were the highest recommended D/ST waiver wire pickups this week.

Analysis

Chiefs — Rostered in 57% of Yahoo Leagues

I’d feel better about this if it weren’t Gardner Minshew at QB for the Chiefs, since that might mean extra drives and better field position for the Titans, but … it’s the Titans. So we’re still streaming the Chiefs defense. They haven’t been great for fantasy, but they also haven’t had the easiest of schedules (by which I mean their schedule has been terrible). Tennessee is as green as it gets.

Read Matt Okada’s full Week 16 Waiver Wire Watch

What is another Matchup to Exploit in the Fantasy Football Defense Rankings?

The Panthers and Bills stick out with a positive matchup during Week 15.

Analysis

Panthers @ Saints

Saints vs. Jets

Don’t look now, but the Saints have won back-to-back games and three of their last five. That might not be great news for their NFL Draft positioning, but it’s certainly made for better viewing. In the four games since their Week 11 bye, their defense ranks in the top 10 in completion rate over expected (-1.0%, 7th), adjusted yards per attempt (4.96, 10th), and pass rate over expected (+10.2%, 9th).

They face off against a Jets team that is failing the end-of-season vibe check and will potentially turn to UDFA rookie Brady Cook once again in Week 16. Through 77 professional dropbacks, Cook has a -3.2% completion rate over expected, five interceptions (on seven turnover-worthy plays), and nine sacks taken. Even if the team turns to Tyrod Taylor or Justin Fields, we shouldn’t be too worried about firing the Saints up as a streaming option.

Bills @ Browns

I typically try to fit two streamable teams in this section every week, but there’s enough wiggle room with the Bills’ ownership that they’re at least worth a look to see if they’re available. Buffalo’s pass rush hasn’t exactly been ferocious (+6.46% PROE, 16th), but getting Joey Bosa back at anything resembling full health will be a good sign against this Browns offensive line that has simply run out of gas. Injuries and inconsistent play have pushed Cleveland into the bottom-10 in every conceivable o-line metric, with the most glaring issues popping up in the running game, where they rank dead-last in both adjusted line yards (3.37) and RB yards before contact (0.65).

Box score TFLs don’t do us much good for fantasy D/STs, but that’s where Shedeur Sanders comes in. Sanders took a season-high five sacks in Week 15 and threw three interceptions, boosting his turnover-worthy play rate to 6.0%, the highest mark of any of the 44 qualifying quarterbacks.

*Read Justin Edwards’ full O-Line Rankings and Matchups to Exploit: Week 16*

Who are some Week 16 Fantasy Defenses to avoid?

Some options that have fallen out of the top-20 Fantasy Football Defense Rankings include: Cincinnati Bengals, Minnesota Vikings, and Miami Dolphins.

For more advice on who to start, check out the Fantasy Football DST Rankings Week 16

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