A pair of the nation’s toughest run defenses clash when the No. 19 Louisville Cardinals (7-2) take college football’s 22nd-ranked run D into a contest with the Clemson Tigers (4-5), who have the No. 20 unit, on Friday, November 14, 2025. The Cardinals are 3-point favorites. The over/under in this outing is 50.5 points.
Louisville vs. Clemson Favorite, Moneyline, Total
Spread favorite: Cardinals (-3) Moneyline: Cardinals (-155), Tigers (+130) Total: 50.5 pointsBest Louisville vs. Clemson Promo Code
How to Watch Louisville vs. Clemson
When: Friday, November 14, 2025 at 7:30 p.m. ET Location: L&N Federal Credit Union Stadium in Louisville, Kentucky TV: ESPN Live Stream: Watch this game on FuboLouisville 2025 Stats & Rankings
Stat Average (Total) Rank Pass yards 246.6 (2219) 50 Rush yards 154.9 (1394) 71 Points scored 32.9 (296) 41 Pass yards against 188.1 (1693) 28 Rush yards against 108.7 (978) 22 Points allowed 21.7 (195) 41Watch NCAA football on ESPN+
Louisville 2025 Betting Info
The Cardinals have compiled a 3-6-0 ATS record so far this year. Louisville is 2-6 against the spread when favored by 3 points or more this season. The Cardinals and their opponent have combined to go over the point total five out of nine times this season. The average total the Cardinals have had set in games this year is 3.7 more points than this outing’s point total. The Cardinals are 1-2 against the spread and 2-1 overall in their past three contests. Twice in those three games, the final combined score has surpassed the set total. The Tigers’ past three outings have ended with an average of 54.5 points scored. That’s 4.0 more points than this contest’s over/under.Louisville Home/Away Splits (2025)
Overall Home Away Point Total AVG 54.2 54.8 52.8 Implied Total AVG 35.8 38.5 30.3 ATS Record 3-6-0 0-6-0 3-0-0 Over/Under Record 5-4-0 4-2-0 1-2-0 Moneyline Favorite Record 6-2 4-2 2-0 Moneyline Underdog Record 1-0 0-0 1-0Watch college football, live sports and entertainment on Fubo! Get started today.
Louisville’s Offense vs. Clemson’s Defense (2025)
The Cardinals average 246.6 passing yards per game (50th in the FBS) compared to the 245.3 per game the Tigers give up (109th in college football). The Cardinals are successful on 39.8% of their third-down plays (72nd in college football). The Tigers’ defense gives up third-down conversions at a 32.5% clip (18th). Louisville has the 71st-ranked rushing offense in the FBS (154.9 yards per game). It faces Clemson’s 20th-ranked rushing defense, which gives up 106.3 on the ground.Clemson 2025 Stats & Rankings
Stat Average (Total) Rank Pass yards 288.4 (2596) 15 Rush yards 120.9 (1088) 112 Points scored 27.9 (251) 72 Pass yards against 245.3 (2208) 109 Rush yards against 106.3 (957) 20 Points allowed 22.4 (202) 53Clemson 2025 Betting Info
Against the spread, the Tigers are 3-6-0 this season. In games it has played as at least 3-point favorites this season, Louisville is 2-6 against the spread. The Tigers have seen three of their nine games hit the over. The average total the Cardinals have had in their games this year is 3.7 more points than this particular game’s point total. The Cardinals are 1-2 against the spread over their last three games, and have a 2-1 straight-up record in those contests. Clemson and its opponents have combined to hit the over two times in those games. The last three Tigers games averaged 54.5 total points, 4.0 more points than this matchup’s point total.Head to Vivid Seats to secure tickets for NCAA football, other live sporting events, concerts and much more!
Clemson Home/Away Splits (2025)
Overall Home Away Point Total AVG 53.3 54.2 51.5 Implied Total AVG 31.9 32.3 31.0 ATS Record 3-6-0 1-5-0 2-1-0 Over/Under Record 3-6-0 3-3-0 0-3-0 Moneyline Favorite Record 3-5 1-4 2-1 Moneyline Underdog Record 0-0 0-0 0-0Clemson’s Offense vs. Louisville’s Defense (2025)
The Tigers’ 120.9 rushing yards per game is good for 112th in the FBS. The Cardinals’ defense allows 108.7 on the ground (22nd in college football). Clemson averages 3.8 yards per carry (102nd in college football) compared to the 3.3 per rushing attempt Louisville gives up (22nd in the FBS). The Tigers are 101st in the FBS in third-down percentage (36.4%), and will be facing the 24th-ranked Cardinals third down defense (33.8%).Louisville vs. Clemson Prediction and Pick
Our prediction for Louisville vs. Clemson sees the Cardinals (-155 on the moneyline) as the pick to win. For the over/under, we recommend betting on the over at 50.5 points.
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