The Chicago Cubs (89-70) host the St. Louis Cardinals (78-81) on Friday to kick off a three-game series at Wrigley Field. The matchup starts at 2:20 p.m. ET.
This contest’s pitching matchup is set, as the Cubs will send Colin Rea (10-7) to the mound, while Miles Mikolas (8-10) will take the ball for the Cardinals.
Cubs vs. Cardinals Pitcher Matchup and Game Info
When: Friday, September 26, 2025 at 2:20 p.m. ET Where: Wrigley Field in Chicago, Illinois How to watch on TV: MLB Network, MARQ, and FDSMW Probable Pitchers: Colin Rea (Cubs) – 10-7, 4.10 ERA vs Miles Mikolas (Cardinals) – 8-10, 4.76 ERACubs vs. Cardinals Odds
Cubs to win:Cubs vs. Cardinals Pitcher Performance
Rea Mikolas 26 GS 30 10-7 W-L 8-10 4.10 ERA 4.76 153.2 IP 151.1 43 BB 36 120 SO 96Cubs Probable Starting Pitcher: Colin Rea
The Cubs are sending Rea (10-7) to make his 27th start of the season. He is 10-7 with a 4.10 ERA and 120 strikeouts through 153 2/3 innings pitched. In his last appearance on Thursday, Sept. 18, the right-hander went seven innings against the Cincinnati Reds, giving up one earned run while surrendering four hits. In 31 games this season, the 35-year-old has an ERA of 4.10, with 7 strikeouts per nine innings. Opponents are hitting .263 against him. Rea heads into this game with seven quality starts under his belt this season. Rea is aiming for his fourth straight appearance lasting five or more innings. He averages 4.9 frames per appearance on the hill. In five of his appearances this season he did not give up an earned run.Cubs vs. Cardinals Promo Codes
Cardinals Probable Starting Pitcher: Miles Mikolas
The Cardinals will send Mikolas (8-10) to the mound for his 31st start this season. The right-hander gave up two earned runs in five innings pitched on Saturday in his last outing, a matchup with the Milwaukee Brewers. The 37-year-old has pitched in 30 games this season with an ERA of 4.76 and 5.7 strikeouts per nine innings, with an opponent batting average of .274. He has started 30 games this season, earning a quality start (6 or more IP, 3 or fewer ER) in eight of them. Mikolas has pitched five or more innings in five straight games and will look to extend that streak. He has made 30 appearances and finished five of them without allowing an earned run.How to Bet on Cubs vs. Cardinals
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