The Chicago Cubs (88-64) will vie for their fifth straight victory when they visit the Cincinnati Reds (76-76) on Thursday at 7:15 p.m. ET on FOX. The Reds are listed as -124 favorites to stop the streak, while the Cubs are +106 underdogs to keep their momentum.
Cincinnati’s Hunter Greene gets the start, and he’ll go against Chicago’s Colin Rea.
Reds vs. Cubs Odds
Reds odds to win: -124 Cubs odds to win: +106 Spread: Reds -1.5 Total: 9 runsReds vs. Cubs Promo Codes
Game Time and Information
Date: Thursday, September 18, 2025 Time: 7:15 p.m. ET TV: FOXWho Will Win Reds vs. Cubs?
Reds and Cubs Betting Trends
The Reds have gone 34-32 in games they were favored on the moneyline (winning 51.5% of those games).
When playing as moneyline favorites with odds of -124 or shorter, Cincinnati has a 21-19 record (winning 52.5% of its games).
The Cubs have been underdogs in 42 games this season and won 18 (42.9%) of those contests.
Chicago has a record of 9-14, a 39.1% win rate, when it’s set as an underdog of +106 or more by sportsbooks this season.
The Reds have played in 149 games with set over/under, and have combined with opponents to go over the total 57 times (57-85-7).
The Cubs and their opponents have hit the over in 69 of their 152 games with a total this season.
Reds Stats & Insights
The Reds rank 13th in runs scored with 682, 4.5 per game.
Cincinnati ranks 23rd in baseball with 153 total home runs.
The Reds rank 16th in the majors with a .246 batting average.
Cincinnati strikes out 8.7 times per game to rank 22nd in MLB.
The 8.6 strikeouts per nine innings compiled by the Reds pitching staff ranks 12th in the majors.
Cincinnati’s 3.98 team ERA ranks 15th across all MLB pitching staffs.
Cubs Stats & Insights
The Cubs have scored the sixth-most runs in the league this season with 743.
Chicago has hit 205 homers this season, which ranks seventh in the majors.
The Cubs’ .250 batting average ranks 12th in the league this season.
Chicago ranks sixth in MLB in strikeouts per game with an average of 7.8 Ks per contest.
The Cubs have a 7.8 K/9 this season as a pitching staff, which ranks 27th in baseball.
Chicago pitchers have a combined ERA of 3.82 ERA this year, seventh-best in baseball.
Reds Key Players to Watch
Greene (6-4) takes the mound for the Reds in his 18th start of the season. He’s put together a 3.01 ERA in 92 2/3 innings pitched, with 116 strikeouts.
Elly De La Cruz leads Cincinnati in home runs with 19 and runs batted in with 82.
TJ Friedl is batting .259 with an OBP of .364 and a slugging percentage of .370 this season.
Spencer Steer has collected 115 base hits, an OBP of .311 and a slugging percentage of .405 this season.
Austin Hays has 98 hits and an OBP of .316 to go with a slugging percentage of .455 this season.
Cubs Key Players to Watch
The Cubs’ Rea (10-6) will make his 26th start of the season.
Nico Hoerner leads the Cubs with a team-best batting average of .303.
Pete Crow-Armstrong’s 29 home runs lead his team.
Ian Happ is batting .243 with 28 doubles, 23 home runs and 85 walks.
Seiya Suzuki has totaled 91 runs batted in to lead his team.
Reds and Cubs Injuries
Reds: Tyler Callihan: 60 Day IL (Forearm), Carson Spiers: 60 Day IL (Shoulder), Wade Miley: 60 Day IL (Flexor), Julian Aguiar: 60 Day IL (Elbow), Brandon Williamson: 60 Day IL (Elbow), Ian Gibaut: 60 Day IL (Shoulder), Rhett Lowder: 60 Day IL (Forearm)
Cubs: Kyle Tucker: 10 Day IL (Calf), Miguel Amaya: 10 Day IL (Ankle), Daniel Palencia: 15 Day IL (Shoulder), Ryan Brasier: 15 Day IL (Groin), Justin Steele: 60 Day IL (Elbow), Eli Morgan: 60 Day IL (Elbow), Owen Caissie: 7 Day IL (Concussion)
Reds vs. Cubs Prediction
Score Prediction: Reds 5, Cubs 4 Total Prediction: Under 9 runsHow to Bet on Reds vs. Cubs
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