A losing streak will come to an end Tuesday when the Chicago White Sox (57-93), losers of three straight, take on the Baltimore Orioles (69-80). The Orioles are hoping to avoid their third loss in a row. The White Sox are -130 favorites to snap out of their slide when the teams hit the field at Rate Field, with first pitch at 7:40 p.m. ET on CHSN and MASN2.
Chicago’s Shane Smith and Baltimore’s Tyler Wells have been named the starters for this contest.
White Sox vs. Orioles Odds
White Sox odds to win: -130 Orioles odds to win: +110 Spread: White Sox -1.5 Total: 8.5 runsWhite Sox vs. Orioles Promo Codes
Game Time and Information
Date: Tuesday, September 16, 2025 Time: 7:40 p.m. ET TV: CHSN and MASN2Who Will Win White Sox vs. Orioles?
White Sox and Orioles Betting Trends
The White Sox have been listed as the moneyline favorite only two other times so far this season, and they split the two games.
Chicago has not yet played a game with moneyline odds of -130 or shorter.
This season, the Orioles have won 38 out of the 84 games, or 45.2%, in which they’ve been the underdog.
This season, Baltimore has won 21 of its 51 games, or 41.2%, when it’s the underdog by at least +110 on the moneyline.
The White Sox have combined with opponents to go over the total 68 times this season for a 68-72-10 record against the over/under.
The Orioles and their opponents have gone over the total this season in 62 of their 149 opportunities.
White Sox Stats & Insights
The White Sox score the fifth-fewest runs in baseball (600 total, four per game).
Chicago averages one home run per game to rank 22nd in baseball with 151 total home runs.
The White Sox have the fourth-worst batting average in the majors (.234).
Chicago strikes out 8.4 times per game, the No. 17 average in the majors.
The pitching staff for the White Sox has a collective eight K/9, which ranks 22nd in MLB.
Chicago has the 20th-ranked team ERA across all MLB pitching staffs (4.22).
Orioles Stats & Insights
The Orioles have scored the 23rd-most runs in the league this season with 635 (4.3 per game).
Baltimore ranks 14th in Major League Baseball with 176 home runs.
The Orioles’ .239 batting average ranks 22nd in the league this season.
Baltimore ranks 25th in MLB in strikeouts per game with an average of 8.9 Ks per contest.
The Orioles have an 8.4 K/9 this season as a pitching staff, which ranks 16th in the big leagues.
Baltimore has the 25th-ranked ERA (4.64) in the majors this season.
White Sox Key Players to Watch
Smith (6-7 with a 3.78 ERA and 122 strikeouts in 131 2/3 innings pitched) gets the start for the White Sox, his 27th of the season.
Miguel Vargas has been key for Chicago with 14 home runs, 53 RBI and a batting average of .232 this season.
Andrew Benintendi is batting .241 with an OBP of .304 and a slugging percentage of .427 this season.
Lenyn Sosa leads Chicago in batting average (.263), home runs (20) and runs batted in (68) this season.
Chase Meidroth has collected 108 hits this season and has an OBP of .347. He’s slugging .344 on the year.
Orioles Key Players to Watch
Wells will get the start for the Orioles, his third of the season.
Gunnar Henderson paces the Orioles with 62 runs batted in while accumulating a team-high batting average of .271.
Jackson Holliday has hit 17 home runs to pace his team.
Ryan Mountcastle has 18 doubles, five home runs and 14 walks while batting .256.
Colton Cowser is batting .201 with 12 doubles, 14 home runs and 22 walks.
White Sox and Orioles Injuries
White Sox: Luis Robert: 10 Day IL (Hamstring), Bryan Hudson: 15 Day IL (Back), Owen White: 15 Day IL (Hip), Elvis Peguero: 15 Day IL (Elbow), Miguel Castro: 60 Day IL (Knee), Ky Bush: 60 Day IL (Elbow), Prelander Berroa: 60 Day IL (Elbow), Drew Thorpe: 60 Day IL (Elbow), Grant Taylor: day-to-day (Groin), Brooks Baldwin: day-to-day (Hip)
Orioles: Jordan Westburg: 10 Day IL (Ankle), Adley Rutschman: 10 Day IL (Oblique), Shawn Dubin: 15 Day IL (Elbow), Colin Selby: 15 Day IL (Hamstring), Albert Suarez: 15 Day IL (Elbow), Felix Bautista: 60 Day IL (Shoulder), Scott Blewett: 60 Day IL (Elbow), Zach Eflin: 60 Day IL (Back), Grayson Rodriguez: 60 Day IL (Elbow), Brandon Young: 60 Day IL (Hamstring), Gary Sánchez: 60 Day IL (Knee), Trevor Rogers: day-to-day (Toe), Dean Kremer: day-to-day (Forearm)
White Sox vs. Orioles Prediction
Score Prediction: White Sox 5, Orioles 4 Total Prediction: Over 8.5 runsHow to Bet on White Sox vs. Orioles
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