The San Francisco Giants (75-74) enter Monday’s matchup with the Arizona Diamondbacks (75-75) following their 1-2 series defeat to the Dodgers. The Diamondbacks, coming off of a series win against the Twins, are listed as -144 favorites for Game 1. The series begins at Chase Field, starting at 9:40 p.m. ET on ARID and NBCS-BA.
Zac Gallen gets the starting nod for Arizona while Kai-Wei Teng is San Francisco’s starter for the contest.
Diamondbacks vs. Giants Odds
Diamondbacks odds to win: -144 Giants odds to win: +121 Spread: Diamondbacks -1.5 Total: 9 runsDiamondbacks vs. Giants Promo Codes
Game Time and Information
Date: Monday, September 15, 2025 Time: 9:40 p.m. ET TV: ARID and NBCS-BAWho Will Win Diamondbacks vs. Giants?
Diamondbacks and Giants Betting Trends
The Diamondbacks have compiled a 43-41 record in games they were favored on the moneyline (winning 51.2% of those games).
In games it has played as moneyline favorites with odds of -144 or shorter, Arizona has gone 20-18 (52.6%).
This season, the Giants have won 29 out of the 61 games, or 47.5%, in which they’ve been the underdog.
San Francisco has entered 23 games this season as the underdog by +121 or more and is 11-12 in those contests.
The Diamondbacks have played in 149 games with an over/under set, and have combined with their opponents to go over the total 72 times (72-69-8).
Games involving the Giants have gone over the total set by oddsmakers in 70 of 149 chances this season.
Diamondbacks Stats & Insights
The Diamondbacks score the fifth-most runs in baseball (743 total, five per game).
Arizona ranks sixth-best in MLB play with 203 total home runs.
The Diamondbacks are 10th in the majors with a .250 batting average.
Arizona’s 8.1 strikeouts per game rank 13th in MLB.
The pitching staff for the Diamondbacks has a collective eight K/9, which ranks 22nd in MLB.
Arizona’s 4.48 team ERA ranks 23rd across all MLB pitching staffs.
Giants Stats & Insights
The Giants have scored 651 runs (4.4 per game) this season, which ranks 16th in MLB.
San Francisco’s 160 home runs rank 19th in Major League Baseball.
The Giants’ .238 batting average ranks 24th in the league this season.
San Francisco ranks 18th with an average of 8.5 strikeouts per game.
The Giants average the 12th-most strikeouts per nine innings (8.6) in the majors this season.
San Francisco has pitched to a 3.85 ERA this season, which ranks eighth in baseball.
Diamondbacks Key Players to Watch
Gallen gets the start for the Diamondbacks, his 31st of the season. He is 11-14 with a 4.84 ERA and 157 strikeouts in 174 2/3 innings pitched.
Geraldo Perdomo leads Arizona in batting average (.286) and runs batted in (95) this season while also slugging 19 homers.
Corbin Carroll leads Arizona in home runs with 30 while driving in 76 runs and slugging .542.
Ketel Marte has 121 hits this season and a slash line of .279/.377/.506.
Gabriel Moreno is batting .292 with an OBP of .349 and a slugging percentage of .462 this season.
Giants Key Players to Watch
The Giants will send Teng (2-4) to the mound for his sixth start this season.
Rafael Devers leads the Giants with 31 home runs and 102 runs batted in.
Jung Hoo Lee’s .266 batting average paces his team.
Willy Adames is batting .232 with 20 doubles, two triples, 28 home runs and 71 walks.
Matt Chapman is hitting .241 with 20 doubles, two triples, 21 home runs and 65 walks.
Diamondbacks and Giants Injuries
Diamondbacks: Tyler Locklear: 10 Day IL (Elbow), Lourdes Gurriel Jr.: 10 Day IL (Acl), Blake Walston: 60 Day IL (Elbow), Corbin Burnes: 60 Day IL (Elbow), A.J. Puk: 60 Day IL (Elbow), Christian Montes De Oca: 60 Day IL (Elbow), Cristian Mena: 60 Day IL (Shoulder), Justin Martinez: 60 Day IL (Elbow), Kevin Ginkel: 60 Day IL (Shoulder), Pavin Smith: 60 Day IL (Quadricep), Tommy Henry: 60 Day IL (Elbow), Blaze Alexander: day-to-day (Elbow)
Giants: Dominic Smith: 10 Day IL (Hamstring), Landen Roupp: 15 Day IL (Knee), Carson Whisenhunt: 15 Day IL (Back), Tom Murphy: 60 Day IL (Back), Randy Rodriguez: 60 Day IL (Elbow), Erik Miller: 60 Day IL (Elbow)
Diamondbacks vs. Giants Prediction
Score Prediction: Diamondbacks 6, Giants 5 Total Prediction: Over 9 runsHow to Bet on Diamondbacks vs. Giants
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