Mizzou took care of business in Week 3 after a 52-10 blowout win over Louisiana. Now, the Tigers will look to make it a 3rd straight 4-0 start as they welcome South Carolina to Faurot Field in Week 4.
According to Circa Sports’ opening lines released on Saturday, Mizzou is a 7-point favorite to beat the Gamecocks at home.
Ahmad Hardy had a monster game for the Tigers against the Ragin’ Cajuns, taking 22 carries for 250 yards and 3 touchdowns. Marquise Davis hit triple digits as well, with 113 yards and a score on 20 attempts. All told, the Tigers registered 427 yards on the ground. Meanwhile, Beau Pribula threw 2 TDs.
South Carolina is licking its wounds after a 31-7 loss to Vanderbilt that dropped the Gamecocks to 2-1. The storyline from that one was an apparent head injury suffered by LaNorris Sellers. According to On3’s Pete Nakos, Sellers suffered a concussion, meaning the Gamecocks would turn to Luke Doty.
In the relatively brief history between the two programs, Mizzou has an 8-6 lead. In 2024, though, South Carolina won 34-30 at Williams-Brice Stadium to snap a 5-game Tigers win streak in the series.
The Tigers haven’t lost to the Gamecocks in CoMo since 2017, though.
College Football?Week 4 Opening Lines Opening App Limits: $3k Sides, $1k Totals pic.twitter.com/aKQ87RBRwo
— Circa Sports (@CircaSports) September 14, 2025Mizzou opens as favorite in Week 4 home game vs. South Carolina Saturday Down South.
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