One team will end a losing skid when the 69-79 Baltimore Orioles (two-game losing streak) and the 57-92 Chicago White Sox (two-game losing streak) meet Monday at 7:40 p.m. ET. The Orioles have been set as -142 favorites by bookmakers for the contest at Rate Field.
Tyler Wells will get the ball for Baltimore while Chicago will counter with Sean Burke.
Orioles vs. White Sox Odds
Orioles odds to win: -142 White Sox odds to win: +120 Spread: Orioles -1.5 Total: 8 runsOrioles vs. White Sox Promo Codes
Game Time and Information
Date: Monday, September 15, 2025 Time: 7:40 p.m. ET TV: CHSN and MASN2Who Will Win Orioles vs. White Sox?
Orioles and White Sox Betting Trends
The Orioles have won 48.4% of the games this season when they were the moneyline favorite (31-33).
Baltimore has gone 11-9 when playing as moneyline favorites with odds of -142 or shorter (55% winning percentage).
This season, the White Sox have won 56 out of the 147 games, or 38.1%, in which they’ve been the underdog.
This season, Chicago has won 39 of its 111 games, or 35.1%, when it’s the underdog by at least +120 on the moneyline.
The Orioles have had an over/under set by bookmakers 148 times, and have combined with opponents to go over the total in 61 of those games (61-82-5).
The White Sox’s games have gone over the total in 68 of their 149 chances.
Orioles Stats & Insights
The Orioles rank 22nd in runs scored with 633, 4.3 per game.
Baltimore is 14th in MLB action with 174 total home runs.
The Orioles rank 23rd in MLB with a .239 batting average.
Baltimore strikes out 8.9 times per game, the No. 25 average in MLB.
The 8.4 strikeouts per nine innings put together by the Orioles pitching staff ranks 16th in MLB.
Baltimore’s 4.59 team ERA ranks 24th across all MLB pitching staffs.
White Sox Stats & Insights
The White Sox are among the lowest scoring teams in the league, ranking 26th with just 598 total runs (four per game) this season.
Chicago ranks 22nd in Major League Baseball with 150 home runs.
The White Sox have a team batting average of just .235 this season, which ranks 27th among MLB teams.
Chicago ranks 17th in strikeouts per game (8.4) among MLB offenses.
The White Sox average the 22nd-most strikeouts per nine innings (eight) in the majors this season.
Chicago pitchers have a combined ERA of 4.23 ERA this year, which ranks 20th in MLB.
Orioles Key Players to Watch
The Orioles are sending Wells (1-0) out for his third start of the season.
Gunnar Henderson leads Baltimore in runs batted in with 62 while batting .270, which is also best on the team.
Jackson Holliday’s 17 home runs are most among Baltimore batters. He’s driven in 55 runs this season while slugging .394.
Ryan Mountcastle is slashing .256/.293/.365 this season for the Orioles.
Colton Cowser is batting .201 with an OBP of .271 and a slugging percentage of .377 this season.
White Sox Key Players to Watch
The White Sox will hand the ball to Burke (4-10) for his 22nd start of the season.
Miguel Vargas is hitting .229 with 30 doubles, two triples, 14 home runs and 50 walks.
Andrew Benintendi has 16 doubles, two triples, 19 home runs and 37 walks while hitting .243.
Lenyn Sosa paces the White Sox with 20 home runs and 68 runs batted in, while putting up a team-high batting average of .263.
Chase Meidroth has 15 doubles, four home runs and 43 walks while batting .269.
Orioles and White Sox Injuries
Orioles: Jordan Westburg: 10 Day IL (Ankle), Adley Rutschman: 10 Day IL (Oblique), Shawn Dubin: 15 Day IL (Elbow), Colin Selby: 15 Day IL (Hamstring), Felix Bautista: 60 Day IL (Shoulder), Scott Blewett: 60 Day IL (Elbow), Zach Eflin: 60 Day IL (Back), Grayson Rodriguez: 60 Day IL (Elbow), Brandon Young: 60 Day IL (Hamstring), Gary Sánchez: 60 Day IL (Knee), Trevor Rogers: day-to-day (Toe), Dean Kremer: day-to-day (Forearm)
White Sox: Luis Robert: 10 Day IL (Hamstring), Bryan Hudson: 15 Day IL (Back), Owen White: 15 Day IL (Hip), Elvis Peguero: 15 Day IL (Elbow), Miguel Castro: 60 Day IL (Knee), Ky Bush: 60 Day IL (Elbow), Prelander Berroa: 60 Day IL (Elbow), Drew Thorpe: 60 Day IL (Elbow), Grant Taylor: day-to-day (Groin), Brooks Baldwin: day-to-day (Hip)
Orioles vs. White Sox Prediction
Score Prediction: White Sox 5, Orioles 4 Total Prediction: Over 8 runsHow to Bet on Orioles vs. White Sox
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