Sassuolo vs Lazio prediction, odds & betting tips – 14/09/2025 ...Middle East

Still seeking their first victory since returning to Serie A, Sassuolo face a difficult test at home, as they host Roman powerhouse Lazio at the Mapei Stadium on Sunday, 14 September.

Keep close tabs on Serie A predictions after viewing our key Sassuolo vs Lazio tips below.

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Sassuolo have lost each of their last five league outings across Serie A and Serie B.The Neroverdi are winless in back-to-back Serie A meetings against Lazio.Lazio won nine of their last 12 Serie A away games as pre-match favourites (D1, L2).The Biancocelesti are on a two-match winless streak away from home in the league.

Correct score prediction: Sassuolo 1-2 Lazio

As the only side yet to earn a point this season, Fabio Grosso’s Sassuolo face a daunting challenge against Lazio in their third Serie A fixture. After a 2-0 opening loss to reigning champions Napoli, they suffered a regrettable 3-2 defeat to underdogs Cremonese.

They now host a Lazio side riding high after a 4-0 victory over Hellas Verona, which helped Maurizio Sarri’s team rebound from a shocking opening day loss to minnows Como.

Sassuolo will be determined to avoid repeating their disastrous top-flight debut season in 2013/14, when they lost all three opening games. But with Lazio’s experience and clinical edge in attack, the visitors are expected to control the match and leave with all three points.

HOME: 5/2 (3.50) – 28.5%DRAW: 12/5 (3.40) – 29.4%AWAY: 21/20 (2.05) – 48.7%

*odds from Ladbrokes, subject to change

The hosts were put to the sword in their first home fixture against Napoli. The Neroverdi remain winless in three straight home league outings, and are priced at 5/2 (3.50) – a minority 28.5% win probability rate.

Lazio will be keen to record their first away win of the league season, as they aim to qualify for European competition this time, after missing out last season. They carry odds of 21/20 (2.05), suggesting a 48.7% chance of victory for the visitors.

One can find all our predictions for today’s games on our football betting tips page.

Most recent H2Hs: Lazio all the way

The two teams played out a 1-1 draw in their previous H2H at Stadio Olimpico last year, before which Lazio secured three 2-0 wins on the trot. Sassuolo’s last H2H win dates back to December 2021.

Italy Serie A 26/05/24

Lazio

Sassuolo

Italy Serie A 21/10/23

Sassuolo

Lazio

Italy Serie A 03/05/23

Lazio

Sassuolo

Italy Serie A 15/01/23

Sassuolo

Lazio

Italy Serie A 02/04/22

Lazio

Sassuolo

Laurs Skjellerup is sidelined for the Neroverdi due to fitness issues, while Kristian Thorstvedt is out with a head injury.

Predicted lineup: Muric (GK), Walukiewicz, Idzes, Muharemovic, Doig, Matic, Kone, Vranckx, Berardi, Pinamonti & Lauriente

Last five matches:

Lazio preview: Favourites to grab maximum points

Sarri has a handful of absentees to deal with: Samuel Gigot, Nicolo Rovella, Manuel Lazzari, Patric and Matias Vecino.

Predicted lineup: Provedel (GK), Marusic, Gila, Romagnoli, Tavares, Guendouzi, Cataldi, Bashiu, Castellanos, Cancellieri & Zaccagni

Last five matches:

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