The NFL season has finally arrived!
Week 1 of the 2025 campaign kicks off on Thursday night when the defending Super Bowl champion Philadelphia Eagles host the Dallas Cowboys. After that, the Chiefs and Chargers go at it Friday night in Brazil. Following the two stand-alone games, we get into our normal Sunday and Monday night schedule. Here’s a look at NFL Week 1 odds for each matchup this weekend.
NFL Week 1 Odds
Dallas Cowboys at Philadelphia Eagles – Thursday, 8:30 PM ET
Spread: Eagles -7.5 Moneyline: Cowboys +315 | Eagles -400 Total Points: Over 47.5 (-110) | Under 47.5 (-110)Kansas City Chiefs at Los Angeles Chargers – Friday, 8:00 PM ET
Spread: Chiefs -3 Moneyline: Chiefs -168 | Chargers +140 Total Points: Over 45.5 (-112) | Under 45.5 (-108)New York Giants at Washington Commanders – Sunday, 1:00 PM ET
Spread: Commanders -6.5 Moneyline: Giants +215 | Commanders -260 Total Points: Over 45.5 (-112) | Under 45.5 (-108)Carolina Panthers at Jacksonville Jaguars – Sunday, 1:00 PM ET
Spread: Jaguars -3.5 Moneyline: Panthers +152 | Jaguars -180 Total Points: Over 46.5 (-118) | Under 46.5 (-104)Pittsburgh Steelers at New York Jets – Sunday, 1:00 PM ET
Spread: Steelers -2.5 Moneyline: Steelers -142 | Jets +120 Total Points: Over 38.5 (-110) | Under 38.5 (-110)Las Vegas Raiders at New England Patriots – Sunday, 1:00 PM ET
Spread: Patriots -2.5 Moneyline: Raiders +122 | Patriots -144 Total Points: Over 43.5 (-120) | Under 43.5 (-102)Arizona Cardinals at New Orleans Saints – Sunday, 1:00 PM ET
Spread: Cardinals -6.5 Moneyline: Cardinals -290 | Saints +235 Total Points: Over 42.5 (-120) | Under 42.5 (-102)Cincinnati Bengals at Cleveland Browns – Sunday, 1:00 PM ET
Spread: Bengals -5.5 Moneyline: Bengals -225 | Browns +188 Total Points: Over 47.5 (-110) | Under 47.5 (-110) Dec 22, 2024; Cincinnati, Ohio, USA; Cincinnati Bengals wide receiver Ja’Marr Chase (1) reacts with quarterback Joe Burrow (9) after scoring a touchdown in the second half against the Cleveland Browns at Paycor Stadium. Mandatory Credit: Katie Stratman – Imagn ImagesMiami Dolphins at Indianapolis Colts – Sunday, 1:00 PM ET
Spread: Colts -1.5 Moneyline: Dolphins -102 | Colts -116 Total Points: Over 46.5 (-120) | Under 46.5 (-102)Tampa Bay Buccaneers at Atlanta Falcons – Sunday, 1:00 PM ET
Spread: Buccaneers -2.5 Moneyline: Buccaneers -132 | Falcons +112 Total Points: Over 47.5 (-110) | Under 47.5 (-110)Tennessee Titans at Denver Broncos – Sunday, 4:00 PM ET
Spread: Broncos -7.5 Moneyline: Titans +330 | Broncos -420 Total Points: Over 42.5 (-110) | Under 42.5 (-110)San Francisco 49ers at Seattle Seahawks – Sunday, 4:00 PM ET
Spread: 49ers -2.5 Moneyline: 49ers -136 | Seahawks +116 Total Points: Over 43.5 (-105) | Under 43.5 (-115)Detroit Lions at Green Bay Packers – Sunday, 4:25 PM ET
Spread: Packers -2.5 Moneyline: Lions +120 | Packers -142 Total Points: Over 47.5 (-105) | Under 47.5 (-115)Houston Texans at Los Angeles Rams – Sunday, 4:25 PM ET
Spread: Rams -3 Moneyline: Texans +124 | Rams -144 Total Points: Over 44.5 (-104) | Under 44.5 (-114)Baltimore Ravens at Buffalo Bills – Sunday, 4:25 PM ET
Spread: Bills -1.5 Moneyline: Ravens -108 | Bills -108 Total Points: Over 50.5 (-115) | Under 50.5 (-105)Minnesota Vikings at Chicago Bears – Monday, 8:15 PM ET
Spread: Vikings -1.5 Moneyline: Vikings -126 | Bears +108 Total Points: Over 44.5 (-104) | Under 44.5 (-118) Aug 17, 2025; Chicago, Illinois, USA; Chicago Bears quarterback Caleb Williams (18) throws the ball during the first half against the Buffalo Bills at Soldier Field. Mandatory Credit: Matt Marton – Imagn ImagesAlways Remember To Bet Responsibly
Betting on sports responsibly is key to making the experience enjoyable and sustainable. Responsible sports betting means setting limits, managing your bankroll wisely, and treating wagers as entertainment rather than a source of income. By betting responsibly, you protect yourself from financial stress while staying in control of your decisions.
It’s important to avoid chasing losses, understand the odds, and only risk money you can afford to lose. Responsible betting also helps you enjoy the games with a clear mind and a balanced perspective, turning sports wagering into a safe, fun, and rewarding part of the fan experience.
Sep 29, 2024; Baltimore, Maryland, USA; Baltimore Ravens quarterback Lamar Jackson (8) leaps across the goal line for a touchdown as Buffalo Bills cornerback Christian Benford (47) and Bills cornerback Cam Lewis (39) defend at M&T Bank Stadium. Mandatory Credit: Geoff Burke-Imagn ImagesGambling problem? Call 1-800-GAMBLER. Available in AZ, CT, CO, IA, IL, IN, KS, KY, LA, MA, MD, MI, NJ, NY, PA, OH, TN, VA, VT, WV, WY only. Full T&C apply.
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