Finally, after months of waiting, it’s back! Get ready to fire up the grill and grab a seat on the couch because college football Week 0 is officially here. The opening weekend is serving up a fun little appetizer before the full-course feast, with a top-25 clash as the main course!
This Saturday, college football kicks things off in Dublin, Ireland, with Iowa State vs Kansas State in the “Farmageddon” rivalry. The Wildcats are a consensus favorite, but this rivalry is always a toss-up, and the Cyclones have taken the last two meetings. So before this overseas matchup kicks off the 2025 college football season, let’s break down its odds and the rest of the Week 0 odds.
College Football Week 0 Odds
*Nathan Ray Seebeck-Imagn ImagesWhile most of the college football world is still in preseason mode, Week 0 offers a handful of games to get the action started, with the highlight being a high-stakes Big 12 showdown. The “Farmageddon” rivalry heads to Dublin, Ireland, as the No. 17 Kansas State Wildcats take on the No. 22 Iowa State Cyclones. Oddsmakers have set a tight line for this matchup, with Kansas State currently a 3 to 3.5-point favorite. The over/under for the game is hovering around 50 points, suggesting another heart stopper between the rivals.
Bettors are split on this one, with some favoring the more experienced Iowa State quarterback Rocco Becht, while others believe Kansas State’s dual-threat quarterback Avery Johnson and their strong rushing attack will be the difference maker. It’s a classic rivalry with Big 12 title implications right out of the gate, making it a must-watch for fans and a key betting opportunity.
Beyond that banger, several other games are on the Week 0 schedule with interesting betting lines. The Kansas Jayhawks, with their newly renovated stadium and returning star quarterback Jalon Daniels, are a solid favorite at home against Fresno State. The line for this game has settled around Kansas -13, though some books have seen a slight movement in favor of the Bulldogs, who are under a new head coach.
Another intriguing matchup is the one between Stanford and Hawaii. What was once a small favorite for Stanford has flipped entirely, with Hawaii now a 2.5-point favorite at home. The line movement suggests a lack of confidence in Stanford’s new coaching staff and a belief that Hawaii, while not a powerhouse, has the home-field advantage and continuity to get the win. Other games include Western Kentucky as a 10.5-point favorite over Sam Houston, and a new look UNLV under Dan Mullen, as a heavy favorite against Idaho State.
College Football Week 0 Odds
*Nirmalendu Majumdar/Ames Tribune / USA TODAY NETWORK via Imagn Images Time | MatchupSpreadTotalMoney12:00 PM ETIowa State+3O 51.5+136Kansas State-3U 51.5-1624:00 PM ETIdaho State+26.5O 65.5+1800UNLV-26.5U 65.5-50006:30 PM ETFresno State+14O 50.5+410Kansas-14U 50.5-5507:00 PM ETSam Houston St+10O 61.5+310Western Kentucky-10U 61.5-3957:30 PM ETStanford+2.5O 50.5+110Hawaii-2.5U 50.5-130Elevate Your Sports Betting Strategy
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