The San Diego Padres (69-56) will try to put a stop to their current four-game losing streak when they host the San Francisco Giants (61-64) at 9:40 p.m. ET on MLB Network, SDPA, and NBCS-BA Wednesday. Bookmakers consider the Padres to be -146 favorites to end their skid, while the Giants are +122 underdogs looking for the upset.
JP Sears will get the ball for San Diego while San Francisco will counter with Landen Roupp.
Padres vs. Giants Odds
Padres odds to win: -146 Giants odds to win: +122 Spread: Padres -1.5 Total: 8 runsPadres vs. Giants Promo Codes
Game Time and Information
Date: Wednesday, August 20, 2025 Time: 9:40 p.m. ET TV: MLB Network, SDPA, and NBCS-BAWho Will Win Padres vs. Giants?
Padres and Giants Betting Trends
The Padres are 40-27 in games they were listed as the moneyline favorite (winning 59.7% of those games).
San Diego has gone 22-16 (winning 57.9% of its games) when it has played as moneyline favorites of -146 or shorter.
This season, the Giants have been the underdog 48 times and won 23, or 47.9%, of those games.
This season, San Francisco has won eight of its 16 games, or 50%, when it’s the underdog by at least +122 on the moneyline.
The Padres have combined with opponents to go over the total 51 times this season for a 51-69-5 record against the over/under.
The Giants and their opponents have gone over the total this season in 56 of their 125 opportunities.
Padres Stats & Insights
The Padres rank 22nd in runs scored with 518, 4.1 per game.
San Diego is second-worst in MLB action with 106 home runs.
The Padres have the eighth-best batting average in the majors (.251).
San Diego’s hitters strike out seven times per game, the third-fewest strikeouts in MLB.
The pitching staff for the Padres has a collective 8.8 K/9, the seventh-best in MLB.
San Diego has a 3.60 team ERA that ranks fourth across all MLB pitching staffs.
Giants Stats & Insights
The Giants rank 25th in the majors with 509 total runs scored this season.
San Francisco has hit just 119 homers this season, which ranks 26th in the majors.
The Giants rank 25th in MLB with a .233 team batting average.
San Francisco ranks 19th with an average of 8.6 strikeouts per game.
The Giants average the 12th-most strikeouts per nine innings (8.6) in the majors this season.
San Francisco pitchers have a combined ERA of 3.69 ERA this year, fifth-best in baseball.
Padres Key Players to Watch
Sears will make his first start of the season for the Padres.
Manny Machado leads San Diego in home runs (20) and runs batted in (72) this season while batting .290.
Fernando Tatis Jr. has 123 hits and an OBP of .368 to go with a slugging percentage of .431 this season.
Luis Arraez’s batting average of .291 leads all San Diego hitters this season.
Xander Bogaerts has 118 hits and an OBP of .332 to go with a slugging percentage of .393 this season.
Giants Key Players to Watch
The Giants will hand the ball to Roupp (7-6) for his 22nd start of the season.
Rafael Devers leads the Giants in home runs (24) and runs batted in (82).
Jung Hoo Lee has 28 doubles, 10 triples, six home runs and 39 walks while hitting .260.
Willy Adames has 18 doubles, two triples, 19 home runs and 57 walks while hitting .222.
Heliot Ramos has a club-leading .267 batting average.
Padres and Giants Injuries
Padres: Michael King: 15 Day IL (Knee), Jhony Brito: 60 Day IL (Forearm), Joe Musgrove: 60 Day IL (Elbow), Jackson Merrill: day-to-day (Ankle)
Giants: Matt Chapman: 10 Day IL (Hand), Jerar Encarnación: 10 Day IL (Hamstring), Erik Miller: 15 Day IL (Elbow), Tom Murphy: 60 Day IL (Back)
Padres vs. Giants Prediction
Score Prediction: Padres 5, Giants 4 Total Prediction: Over 8 runsHow to Bet on Padres vs. Giants
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