How this common chemotherapy drug can raise risk of severe damage to heart ...Middle East

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How this common chemotherapy drug can raise risk of severe damage to heart
New Delhi, July 18 (IANS) US researchers have uncovered how the most common chemotherapy drug doxorubicin causes severe cardiac damage. The study, published in the journal Nature Cardiovascular Research, shows that doxorubicin activates CD8+ cytotoxic T-cells, which then migrate to the heart and cause inflammation and fibrosis, leading to stiffness of the heart and impaired function. This mechanism was observed in mice, dogs, and human lymphoma patients. The team at Tufts University found that these T-cells, typically involved in combating viruses, mistakenly target heart tissue after doxorubicin treatment. Blocking T-cells from entering the heart could potentially prevent this damage. Futur

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