Diversity in typhoid bacteria linked to higher mortality rates ...Middle East

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Diversity in typhoid bacteria linked to higher mortality rates
Nature Communications (2024). DOI: 10.1038/s41467-024-49590-6"> The presence of clinical missense mutations leads to alterations in the mechanism of action of TviE and TviD. Credit: Nature Communications (2024). DOI: 10.1038/s41467-024-49590-6 Worldwide, 20% of the bacterial strains that cause typhoid fever have genetic variations in their external layer, called Vi capsule, that provide higher virulence, higher infectivity and high antibiotic resistance, Cornell researchers have discovered, possibly impacting the disease’s propagation and vaccine efficacy. The study, published June 19 in Nature Communications, marks the first time these variant

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