Study decodes how long-term pesticide exposure raises Parkinson’s risk ...Middle East

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Los Angeles, April 25 (IANS) Rare gene variants may explain why long-term pesticide exposure spikes the risk of developing Parkinson’s disease, a study said on Thursday. Although pesticide exposure is linked to Parkinson’s disease risk, the new study sought to explain why some individuals with high exposure develop the disease while others do not. Researchers from the University of California-Los Angeles (UCLA) found that variants in some rare gene variants were enriched in patients with more severe Parkinson’s disease who also had higher exposure to pesticides. “These variants also appeared to be deleterious to protein function suggesting that disruption of lysosomal activity may be underly

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