Researchers take closer look at DNA repair scheme for cancer therapy ...Middle East

Business Standard - Economy
source : Business Standard ( Middle East ) () 46
Researchers from Rice University and St. Jude Children's Research Hospital in Memphis, Tennessee, have taken a closer look at one of the ways cells repair broken strands of DNA.They discovered details that could help make a particular enzyme a promising target for precision cancer therapy.Not unlike patching a tire, the job of DNA polymerase theta (aka Pol theta) is to fix double-strand breaks in DNA, bridging the hanging single-stranded ends and catalyzing DNA synthesis across the break, a process known as microhomology-mediated end joining (MMEJ).MMEJ is complementary to two other processes -- homologous recombination and non-homologous end joining -- that repair DNA double-strand breaks,

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