This time the 49ers couldn’t overcome another barrage of injuries to their defense.A week after the 49ers earned a 20-10 prime-time home wi...

The 49ers have played some good football this season.The 49ers have played some bad football this season.But Sunday was something else ent...

The only good thing you can say about the 49ers’ performance Sunday in Houston was that things improved.Then again, there was truly nowhere...

At least it's not bad news for the Niners.

The 49ers finally have picked off an opponent in the 2025 season.

Follow along with our live updates at the bottom of this story…HOUSTON — Ricky Pearsall is out a fourth straight game, and Brandon Aiyuk’s...

SANTA CLARA — Charles Woodson understands what Brock Purdy is going through. The term “turf toe” may sound innocuous, but it can can be debi...

HOUSTON – Apologies to data analysts and numbers crunchers but one of Stanford’s most distinguished alumni has something to say.“You can lo...

The San Francisco 49ers take on the Houston Texans at 10 a.m. PT on Sunday, Oct. 26 at NRG Stadium in Houston.The Niners are coming off con...

SANTA CLARA — The 49ers got some good news in the here and now with cornerback Deommodore Lenoir rejoining practice with the likelihood he’l...

"He's like a Kyle Shanahan  on defense," Nick Bosa said.

The San Francisco 49ers will be starting Mac Jones in Week 8 as Brock Purdy will miss another game with injury.

San Francisco 49ers general manager has revealed a huge update on the timeline return for Brandon Aiyuk.

49ers general manager John Lynch is reportedly working the phones, looking to update his team's roster by making a trade.

SANTA CLARA — DeMeco Ryans is in his third season as coach of the Houston Texans, something he never knew he wanted until Kyle Shanahan sat...