San Francisco 49ers tight end George Kittle is injured.

“Probably can't go with him as much as we'd usually do.”

SEATTLE — Christian McCaffrey insisted Thursday’s calf issue was “nothing serious,” and the 49ers agree to the point they’ll play him in tod...

In his first public comments, Papa said he's battling a form of leukemia.

Brock Purdy insisted “my mindset hasn’t changed” upon signing a five-year, $265 million contract extension this spring.Others, however, may...

McCaffrey is questionable for Week 1 with a calf injury.

Target these two underdogs in Week 1.

49ers star defensive end Nick Bosa has some big goals for the new NFL season.

This is it for the 49ers’ duo of head coach Kyle Shanahan and general manager John Lynch.No, the duo isn’t on the hot seat, but consider th...

SANTA CLARA – The 49ers were mostly inert during free agency this offseason, choosing instead to focus on contract extensions with franchise...

49ers fans traveling to Seattle can do so with some added peace of mind.

The time for optimism and hope is over.It’s time for the cold, harsh reality of another NFL regular season.This isn’t just a game for toug...

SEATTLE – This is where it all starts for the 49ers, whose ultimate finish line is back home at Levi’s Stadium, site of Super Bowl LX in fiv...

Kyle Juszczyk's wife, Kristin, shared a glimpse of her San Francisco 49ers ladies' party ahead of the team's season opener.

The California Lottery has announced an NFL-themed partnership to celebrate the new season, releasing a series of scratchers featuring the L...