The San Francisco 49ers battle the Arizona Cardinals in their home opener at Levi’s Stadium on Sunday, Sept. 21 at 1:25 p.m. PDT.The Niners...

SANTA CLARA – All-white throwback jerseys are to serve as the 49ers’ heat shield if Sunday’s home opener with Arizona turns into another sco...

With the Arizona Cardinals taking on the San Francisco 49ers in Week 3 (Sunday at 4:25 p.m. ET), is Kyler Murray a good bet to hit paydir...

Will Marvin Harrison Jr. cash his Week 3 anytime TD player prop when the Arizona Cardinals clash with the San Francisco 49ers on Sunday a...

Purdy missed last Sunday’s 26-21 49ers win over the Saints in New Orleans. 

TEMPE — The San Francisco 49ers won’t be the only force going against the Arizona Cardinals this week.Adversity has taken centerstage and...

SANTA CLARA. Calif. (AP) — Quarterback Brock Purdy is “highly unlikely” to start on Sunday for the San Francisco 49ers as he deals with a to...

SANTA CLARA — Whether the quarterback is Mac Jones or Brock Purdy, it’s all about forward progress for the 49ers.Purdy was officially liste...

San Francisco 49ers head coach Kyle Shanahan has revealed whether Brock Purdy will play in Week 3.

SAN FRANCISCO (AP) — The teen charged with shooting San Francisco 49ers wide receiver Ricky Pearsall during an attempted robbery last year w...

He was a crucial member of the 49ers dynasty in the 80s, playing linebacker for 82 games in San Francisco.

SANTA CLARA — As Fred Warner basked Sunday in the 49ers’ 2-0 start, he credited their defense’s clutch finishes to this simple task: “Nobody...

Will 49ers quarterback Brock Purdy be able to return to action this Sunday versus the Cardinals?

Carved up. That’s about the best way to explain what Arizona Cardinals quarterback Kyler Murray did to the San Francisco 49ers last year.H...

SANTA CLARA — The 49ers may be leaning toward Mac Jones to make a second consecutive start Thursday, but weren’t ready to declare their inte...