Arizona Cardinals quarterback Jacoby Brissett couldn’t be bothered by the NFL record he set on Sunday because it came in spite of a 41-22 lo...

The 49ers beat the Cardinals on Sunday 44-22, dominating their NFC West opponents in Arizona.San Francisco led wire-to-wire after Skyy Moor...

GLENDALE, Ariz. (AP) — Brock Purdy threw three touchdown passes in his return from a toe injury, Christian McCaffrey had two rushing touchdo...

Up and down the 49ers’ season goes.The lows? They’ve been pretty low.But the highs, like Sunday’s 41-22 win over the Cardinals? Those are...

The Arizona Cardinals set a new franchise record during a 41-22 loss to the San Francisco 49ers on Sunday, but not the good kind.Tight end...

GLENDALE, Ariz. – Skyy Moore nearly upstaged Brock Purdy’s comeback and Arizona homecoming. Moore returned Sunday’s opening kickoff 98 yards...

GLENDALE — Arizona Cardinals running back Emari Demercado exited the second quarter of his team’s game against the San Francisco 49ers with...

The 49ers defense could have gotten off the field if not for the penalty.

It didn’t take long for the Valley’s own Brock Purdy to get on the board with a San Francisco 49ers touchdown against the Cardinals in his t...

Deommodore Lenoir is good to go for the 49ers today against the Arizona Cardinals.Lenoir was listed as questionable Friday with a calf inju...

GLENDALE — Arizona Cardinals defensive lineman Walter Nolen III and cornerback Max Melton are officially active for Sunday’s game against t...

Target these two road favorites in Week 11 NFL betting.

The 49ers rewarded defensive end Clelin Ferrell by signing him to the 53-man roster Saturday and flexed cornerback Eli Apple from the practi...

Cardinals left tackle Paris Johnson Jr. said he’s never seen anything like it.The 49ers have.Arizona couldn’t practice to start the week....

GLENDALE, Ariz. – Linebacker Tatum Bethune quickly nixed any comparisons between Arizona Cardinals tight end Trey McBride and 49ers counterp...