SANTA CLARA — Season’s greetings and thank you for the 49ers social-media queries that filled this Week 17 mailbag:Should the 49ers try to...

If you hadn’t noticed, the 49ers’ Kyle Shanahan is in the conversation for NFL Coach of the Year.It’s hard to miss since every talking head...

SANTA CLARA — It’s not worth fretting over the possible loss of 49ers defensive coordinator Robert Saleh during the next NFL head coaching c...

Trent Williams said following San Francisco's 48-27 victory over the Colts on Monday night that he's "nowhere near done."

There was no on-field Christmas joy for Indianapolis.

A second-quarter catch by Kendrick Bourne during "Monday Night Football" only picked up 11 yards for the 49ers, but it ended up being worth...

The receiver's speedy drive by the 49ers' stadium has the attention of local police.

The 49ers had six players named to the Pro Bowl roster announced early Tuesday morning, including multi-time honorees fullback Kyle Juszczyk...

INDIANAPOLIS – Here is how the 49ers (11-4) graded in Monday night’s 48-27 win over the host Colts (8-7):PASS OFFENSE: ABrock Purdy threw...

It wasn’t so long ago there were those among the fan base and the media openly wondering if giving Brock Purdy a five-year contract worth a...

The 44-year-old grandfather looked like he was throwing the football without a thumb. He had been retired for five years, presumably spendin...

The 49ers’ turbocharged offense led them to a 48-27 win over the Indianapolis Colts on Monday night, giving them a fifth consecutive victory...

By MICHAEL MAROT AP Sports WriterINDIANAPOLIS — Brock Purdy and the San Francisco 49ers kept winning and did their neighbors to the south a...

In the middle of a quarterback shootout, the 49ers saw another one of their key offensive pass options go down.

It was truly a costly mistake.