The San Francisco 49ers are taking on the Indianapolis Colts at 5:15 p.m. PDT on Dec. 22 at Lucas Oil Stadium on Monday Night Football.The...

Pittsburgh's win means the Chicago Bears and San Francisco 49ers clinched spots in the playoffs.

The San Francisco 49ers (10-4) bring a four-game winning streak into a matchup against the Indianapolis Colts (8-6) on Monday, December 22...

The 49ers clinched a playoff berth Sunday courtesy of the Pittsburgh Steelers.When the Steelers held on to beat the Detroit Lions 29-24 Sun...

The San Francisco wideout posted a video of himself going on a joyride in his Cadillac on Saturday, ripping through the South Bay and hittin...

Around the AFCNo problems, Houston. Six weeks ago, who could have foreseen the AFC South being one of the best races out there and not incl...

INDIANAPOLIS – Time for another inspiring reminder about Brock Purdy’s rise from NFL irrelevancy.It’s been three years and 10 months since...

The San Francisco 49ers (10-4) will visit the Indianapolis Colts (8-6) on Monday at 8:15 p.m. ET. Keep scrolling for DFS analysis.49ers v...

Aiyuk’s behavior has led some to publicly express concern.

Once 7-1, the Colts have lost five of six and are desperate for a win. The 49ers have won four straight to improve to 10-4. We’ve got the ke...

Here's how the 49ers could end up with a playoff bye.

There's more about Brandon Aiyuk the Niners aren't telling us.

SANTA CLARA – The 49ers’ path to and through the NFC playoffs could be dictated by tonight’s matchup in Seattle, where the Seahawks host the...

His first 49ers game back on the airwaves is set to come on Dec. 28 versus the Bears.

With Greg Papa on screen on the KNBR youtube channel wearing a broad smile and clean shaven for the first time in months, it was announced t...