Slc20a1b is essential for hematopoietic stem/progenitor cell expansion in zebrafish ...Middle East

Hematopoietic stem and progenitor cells (HSPCs) can give rise to all blood lineages throughout their lifetime, yet the mechanisms regulating HSPC development have yet to be discovered. In this study, researchers found that the mutation of zebrafish slc20a1b gene would block the cell cycles of HSPCs at G2/M phase in a cell-autonomous fashion. This study shows that slc20a1b is a vital regulator for HSPC proliferation and provides valuable insights into HSPC development.

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