Steve Borthwick's side come into the clash on the back of their 45-22 victory against Australia last weekend which left England second in the northern hemisphere pool and just two points behind France.
England, who beat Japan 59-14 in their last meeting in 2024, are yet to lose against the Brave Blossoms in their history and they'll fancy their chances of keeping that run going on Saturday.
Read more: Nations Championship TV schedule
The game takes place at the Allianz Stadium, Twickenham, in London.
What time does England v Japan kick-off?
Check out the Nations Championship TV schedule with our comprehensive guide.
What TV channel is England v Japan on?
Rugby experts and former players will provide plenty of build-up to the big game in the run-up to kick-off.
Every match of the tournament will be shown live across ITV platforms.
Fans can tune in to watch all the action live and on the move via a range of device, including smartphones and tablets via the ITVX app.
Is England v Japan on radio?
BBC Radio 5 Live is available on DAB radio, MW 693 kHz, 909 kHz and 990 kHz, or you can tune into the station via most TV packages. You can also listen to Radio 5 Live online via the BBC website or BBC Sounds app.
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England v Japan odds
In working partnership with the Radio Times, bet365 has provided the following betting odds for this event:
bet365 odds: England (1/150) v Japan (18/1)*
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*Odds subject to change. 18+. T&Cs apply. GambleAware.org. Note – The bonus code RT365 does not change the offer amount in any way.
Check out more of our Sport coverage or visit our TV Guide and Streaming Guide to find out what's on. For more TV recommendations and reviews, listen to The Radio Times Podcast.
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