The research, published Sept. 30 in the journal PLOS One, found that rats exposed to levels of radiation similar to what an astronaut might experience on a long-term trip to Mars developed more scar tissue around the small blood vessels of their hearts than rats that were not exposed to this radiation. This scar tissue is indicative of a condition known as cardiac fibrosis, which is known to increase the risk of heart failure.
But since this study was in rats, it cannot definitively say whether this effect will play out in humans. For example, given that humans have a longer life expectancy than rats (80 years versus 2 to 4 years), the effects seen in rats may take around 30 years to show up in humans. However, the study authors say the research highlights the importance of following astronauts' health long after they return to Earth.
How space radiation affects the heart
The link between exposure to radiation and cardiac issues has been well documented. However, "no astronaut has ever been exposed to galactic cosmic radiation for long periods of time," Baker said, which makes it difficult to determine exactly how space radiation affects the heart.
During the study, the researchers exposed rats to several minutes of radiation proportionate to their size, similar to what they might experience on a trip to Mars and back (a roughly 18-month round trip, with current technology). Some of the rats' hind legs were suspended, to "simulate conditions of weightlessness," Baker said.
This effect was not seen in the rats who were exposed only to simulated weightlessness, confirming "it was only the radiation that produced the damaging effect on the heart," Baker said. However, long-term testing revealed that this group of rats had lower levels of key immune cells, suggesting that microgravity also may affect aspects of long-term health. (Numerous studies have shown various short-term health impacts related to microgravity.)
Related storiesThis study "is a very valuable contribution to space biology," Rupak Pathak, an associate professor of pharmaceutical science at the University of Arkansas for Medical Sciences who was not involved in the study but holds a doctorate in radiation biology, told Live Science. While rats and humans have clear differences, "they share more than 90% of genetic information," he said, as well as very similar cardiac systems.
Baker and his colleagues hope that future experiments can be used to help NASA implement safeguards for astronauts on long-term missions, such as providing astronauts heart medications or improving shielding for the spacecraft.
"The more we know before we start, then the better NASA is going to be at working out what types of countermeasures can be developed," said Baker.
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